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논문명/저자명
Influence of the IL-6 -572C>G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men = 남성에서 흡연에 따른 Interleukin-6 -572 promotor 유전자 다형성이 염증성 인자에 미치는 영향 / 신경균
발행사항
서울 : 연세대학교 대학원, 2007.8
청구기호
TD 613.85 ㅅ563i
형태사항
viii, 47 p. ; 26 cm
자료실
전자자료
제어번호
KDMT1200774205
주기사항
학위논문(박사) -- 연세대학교 대학원, Aging and Clinical Nutrition, 2007.8
원문
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title page

Acknowlegdments

Contents

Abstract 12

I. Preface 15

II. Background 17

2.1. Interleukin-6 (IL-6) and Interleukin-6 (IL-6) gene 17

2.2. Inflammation and CVD 21

2.3. Relationship between plasma levels of IL-6 and CVD 23

2.4. Relationship between genotypes of IL-6 and CVD 24

2.5. IL-6 -174G>C promotor polymorphism and the risk of CHD 26

2.6. Relationship between genotypes of IL-6 and plasma levels of IL-6 27

2.7. Relationship between genotypes of IL-6 and insulin 30

III. Influence of the IL-6 -572C>G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men 31

3.1. Introduction 32

3.2. Subjects and methods 34

3.2.1. Study subjects 34

3.2.2. Anthropometric parameters, blood pressure measurements and blood collection 35

3.2.3. Genotyping of interleukin-6 at positions -174(G〉C) and -572(C〉G), -597(G〉A) and -1363(G〉T) 36

3.2.4. Serum lipid profiles and glucose and insulin concentrations 37

3.2.5. Circulating concentrations of IL-6, CRP, fibrinogen and oxidized LDL 38

3.2.6. Urine collection and 8-epi-prostaglandin F2α 39

3.2.7. Statistical methods 40

3.3. Results 41

3.3.1. Main characteristics of the study subjects 41

3.3.2. Genotypes and allele frequencies of the IL-6-174G>C and -572C>G, -597G>A and -363G>T polymorphisms 43

3.3.3. Clinical characteristics according to IL-6 -572C>G polymorphism 44

3.3.4. Relationship between IL-6 -572C>G polymorphism and circulating levels of IL-6, CRP, fibrinogen or oxidative stress 45

3.3.5. Relation of IL-6 concentrations to CRP and fibrinogen and oxidative stress in all subjects 48

3.4. Discussion 49

IV. References 53

구문요약 60

Table 1. Main characteristics of non-smokers and smokers 42

Figure 1. Structure of interleukin-6 (IL-6) 17

Figure 2. Biologic activities of interleukin-6 18

Figure 3. IL-6 genomic structure and polymorphism location 19

Figure 4. IL-6 and CRP concentrations in relation to smoking and the IL-6 -572C>G polymorphism in 644 healthy men 46

Figure 5. Fibrinogen and ox-LDL concentrations and urinary excretion of 8-epi-PGF 2α in relation to smoking and the IL-6 -572C>G polymorphism in 644 healthy men 47

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