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ABSTRACT

목차

Ⅰ. 서론 7

Ⅱ. 실험 재료 및 방법 13

1. 실험재료 13

⑴ 실험동물 13

⑵ 연구재료 및 기기 13

2. 실험방법 13

⑴ 일반적인 188Re-DPD의 표지 13

① Sncl2·2H2O 농도의 영향 14

② pH의 영향 14

③ 가열시간의 영향 15

④ DPD 농도의 영향 15

⑤ 담체 농도의 영향 15

⑵ 188Re-DPD의 안정도 측정 16

⑶ 마우스에서 188Re-DPD의 생체 내 분포 16

⑷ 랫트의 영상 17

⑸ 통계학적 분석 17

Ⅲ. 결과 18

1. 188Re-DPD의 합성에 영향을 미치는 인자 18

① Sncl2·2H2O 농도의 영향 18

② pH의 영향 18

③ 가열시간의 영향 18

④ DPD 농도의 영향 19

⑤ 담체 농도의 영향 19

⑵ 188Re-DPD의 안정도 측정 결과 19

⑶ 마우스에서 188Re-DPD의 생체 내 분포 19

⑷ 랫트의 영상 20

Ⅳ. 고찰 30

Ⅴ. 요약 34

Ⅵ. 참고문헌 35

그림목차

Figure 1. Chemical structure of diphosphonate complexes 7

Figure 2. Effect of the concentration of stannous chloride on the radichemical yield of 188Re-DPD using carrier free 188Re. 188Re-DPD showed 96.9% of radiochemical yield with 1.0 mg/ ml of reducting agent at pH 1. (pH 1, 100℃/30 min, glutamic acid 1.0 mg 21

Figure 3. Effect of pH on the radiochemical yield of 188Re-DPD using carrier free 188Re. 188Re-DPD showed ]90 % radiochemical yield at acidic PH, radiochemical yield dec reased at pH higher than 3. (DPD 0.05 mmol/ml, SnCl2� 2H2O 1.0 mg/ml, glutamic acid 1.0 mg/ml) 22

Figure 4. Effect of reaction time radiochemical yield of 188 Re-DPD using carrier free 188Re at boiling water 188Re-DP D showe d th e h ig h est rad ioch emical y ield at 6 0min at p H 1 . (DPD 0.05 mmol/ml, SnCl2�2H2O 1.0 mg/ml, glutamic acid 1.0 mg/ml, pH 1) 23

Figure 5. Effect of the concentration of DPD using carrier free 188Re. 188Re -DPD showed 96.4% of radiochemical yie ld with 0.05 mmol/ml of ligand. (pH 1, 100℃/30 min, SnCl2 ·2H2O 1.0 mg/ml, glutamic acid 1.0mg/ml) 24

Figure 6. Effect of concentration on carrer of 188Re-DPD. Ammonium perrhenate was used as carrier. After 188Re-perr henate 370 MBq/ml was added to this individual concentration, It was boiled in 100℃ for 30 min and we measured radiochemical purity. 188Re 25

Figure 7. Anterior views whole body images of rats. 26

표목차

Table 1. Biodistribution of 188Re-DPD in rats 27

Table 2. Bone to muscle uptake ratios in rats at different time after the injection of DPD 28

Table 3. Bone to blood uptake ratios in rats at different time after the injection of DPD 29