Contents
Determination of cut-off value by receiver operating characteristic curve of norquetiapine and 9-hydroxyrisperidone concentrations in urine measured by LC-MS/MS / Seon Yeong Kim ; Dong Won Shin ; Jin Young Kim 1
Abstract 1
1. Introduction 1
2. Experiment 3
2.1. Chemicals and reagents 3
2.2. Urine samples 3
2.3. LC-MS/MS conditions 3
2.4. Sample pretreatment 4
2.5. Method validation 4
2.6. Statistical analysis 4
3. Results and Discussion 4
3.1. LC-MS/MS analysis 4
3.2. Method validation 5
3.3. Forensic applications 5
3.4. Comparison of drug concentration distribution by gender 5
3.5. ROC analysis and optimal cut-off value 6
4. Conclusions 8
Supplemental Material 8
References 8
Authors' Posotions 9