Contents
Development of jaspine B analysis using LC-MS/MS and its application : dose-independent pharmacokinetics of jaspine B in rats / Im-Sook Song ; Ji-Hyeon Jeon ; Jihoon Lee ; Dong Yu Lim ; Chul Haeng Lee ; Dongjoo Lee ; Min-Koo Choi 1
Abstract 1
1. Introduction 1
2. Experimental 2
2.1. Chemicals and reagents 2
2.2. Preparation of the stock and working solutions 2
2.3. Preparation of calibration standards and quality control samples 2
2.4. Sample preparations 3
2.5. LC-MS/MS conditions 3
2.6. Method validations 3
2.7. Pharmacokinetic study 3
2.8. Data analysis and statistics 5
3. Results 5
3.1. LC-MS/MS analysis of Jaspine B 5
3.2. Selectivity 5
3.3. Precision and accuracy 5
3.4. Matrix effect and recovery 5
3.5. Stability 5
3.6. Pharmacokinetic 6
4. Discussion 7
5. Conclusions 8
References 8
Authors' Positions 9