Contents
1H-NMR and HPLC analysis on the chiral discrimination of β-blockers using (S)-2-tert-butyl-2-methyl-1,3-benzodioxole-4-carboxylic acid / Sang Hun Seo ; Xuan-Lan Mai ; Thi-Anh-Tuyet Le ; Kyeong Ho Kim 1
Abstact 1
1. Introduction 1
2. Experimental 2
2.1. Chemicals and reagents 2
2.2. Instrumentation 2
2.3. Isolation of β-blocker enantiomers 3
2.4. Derivatization of β-blockers 3
2.5. ¹H-NMR study 3
2.6. HPLC conditions 3
2.7. Analysis of chiral purity of (S)-METO 3
3. Results and Discussion 4
3.1. Isolation of β-blocker enantiomers 4
3.2. Derivatization of β-blockers 4
3.3. Chiral discrimination of β-blockers by ¹H-NMR 5
3.4. Chiral separation of β-blockers by HPLC 6
3.5. Determination of chiral purity of (S)-METO by developed method 6
4. Conclusions 7
References 7
Authors' Position 8