본 연구는 대학생의 소명이 진로적응성에 미치는 영향을 확인하고, 소명과 진로적응성의 관계를 의미 추구와 의미 발견의 과정이 매개하는지 확인하고자 하였다. 이를 위해 서울 소재 4년제 대학교 재학생 245명(남학생 117명, 여학생 128명)을 대상으로 소명 척도, 의미 추구 척도, 의미 발견 척도, 진로적응성 척도를 사용하여 자료를 수집하고, SPSS 25.0과 SPSS Macro를 활용하여 수집된 자료를 분석하였다. 매개모형은 위계적 회귀분석을 통해 검증하였으며, 부트스트래핑 방식을 활용하여 매개효과의 통계적 유의성을 확인하였다. 본 연구의 주요 결과는 다음과 같다. 첫째, 진로적응성은 소명, 의미추구, 의미발견 모두와 유의미한 상관을 보였다. 둘째, 소명은 진로적응성에 직접적으로 정적인 영향을 미쳤다. 셋째, 소명과 진로적응성의 관계를 의미추구와 의미발견이 순차적으로 부분매개하였다. 이러한 연구결과를 바탕으로 실제 상담 장면에서의 적용과 한계점, 그리고 후속연구에 대한 제언을 논의하였다.Only a few studies have investigated the influence of career calling on career adaptability and the mechanisms behind this relationship, so this investigated how the search for and presence of meaning, the two elements of meaning in life, affect this relationship. 247 Participants completed a survey on career calling, career adaptability, the search for meaning and the presence of meaning. Correlational analysis was conducted to examine the relationships between the research variables. A serial multiple mdediating effects test was conducted to test the proposed mediating effects. Finally, a bootstrapping procedure was used with SPSS Macro to test the significance of the indirect effects. The results were as follows: First, career calling was positively related with career adaptability. Second, the search for and presence of meaning both partially mediated the relationship between career calling and career adaptability. This result implies that the search for meaning alone can lead to positive outcomes, such as increasing career adaptability, a result not found in previous studies. Third, the relationship between career calling and career adaptability was sequentially mediated by the search for meaning and the presence of meaning. This paper ends with a discussion of implications of this study’s results in clinical practice and this study’s limitations.