Objective : This study was designed to investigated effects of Gleditsia spina (GS) on human derived
melanoma cells
Methods : The genetic profile for the effect of medicine on human derived melanoma cells of SK-MEL-2, was
measured by using microarray technique, and the functional analysis on these genes was conducted. The network
of total protein interactions was measured by using cytoscape program.
Results : Total 253 genes were up-regulated and 439 genes down-regulated in cells treated with GS. Genes
induced or suppressed by GS were all mainly concerned with metabolic process, regulation of biological process
and protein binding.
Conclusion : Suggest the possibility of GS as anti-cancer drug and cosmetic agent, and also suggest that
related mechanisms are involved in regulation of intra-cellular metabolism in melanoma cells.