Title Page

Contents

Abstract 10

Ⅰ. Introduction 12

Ⅱ. Methods 15

1. Patient selection 15

2. Neuropsychologic tests 16

A. Korean-Wechsler Preschool and Primary Scale of Intelligence-IV 16

B. The Beery-Buktenica Developmental Test of Visual-Motor Integration 16

C. Social Maturity Scale 16

D. Childhood Autism Rating Scale-Second Edition (CARS-2) 17

3. Statistical analysis 17

Ⅲ. Results 19

1. Comparison of neuropsychologic assessment scores between ASD and ID/BIF groups 19

2. Differential factors between ASD and ID/BIF groups using K-WPPSI-IV 20

3. Relationship between neuropsychologic assessment scores and CARS-2 in ASD 21

Ⅳ. Discussion 23

1. Discriminating preschool-age ASD from that of ID/BIF 23

2. Correlation between neuropsychologic profiles and symptom severity of ASD 26

3. Limitation and Strength 28

Ⅴ. Conclusion 29

Ⅵ. Reference 30

Abstract 46

Table 1. Clinical characteristics of ASD and ID/BIF patients 34

Table 2. Comparison of the K-WPPSI-IV subtests' scores, the Beery VMI score, and SQ after statistical adjustment between ASD and ID/BIF groups 35

Table 3. Differences between the subtests of K-WPPSI-IV using a one-way t-test for ASD and ID/BIF 36

Table 4. ROC curve analysis of subtest differences for distinguishing between ASD and ID/BIF 37

Table 5. Relationship between CARS-2 scores and developmental assessment scores in ASD patients 38

Figure 1. Algorithm of patient selection 39

Figure 2. Box-and-Whisker plot of K-WPPSI-IV subtests for ASD and ID/BIF 40

Figure 3. Correlation between FSIQ, the Beery VMI scores, and SQ 41

Figure 4. ROC curve comparisons of "VCI-FRI" and "VCI-WMI" for distinguishing between ASD and ID/BIF 43

Figure 5. Correlation between cognitive profile and CARS-2 score in ASD 44