Title Page

Contents

ABSTRACT 8

제1장 Introduction 9

제2장 Methods 11

1. Patients 11

2. Cell culture 11

3. Quantitative reverse-transcription polymerase chain reaction 12

4. Statistical analysis 13

제3장 Results 14

1. Retrospective review of 13 cases 14

2. In vitro analysis of the effects of 9-cis-retinoic acid on keratinocytes 15

제4장 Discussion 20

제5장 Conclusions 22

제6장 References 23

ABSTRACT KOREAN 26

Table 1. Patient's baseline characteristics and response to alitretinoin 17

Figure 1. Clinical photographs before and after treatment with alitretinoin. (A, B) Before treatment. (C, D) After treatment. 15

Figure 2. Decreased mRNA expression of inflammation regulatory in alitretinoin-treatment HEKs. HEKs were cultured without serum for 16 h,... 16