표제지
국문초록
목차
List of Abbreviations 14
Ⅰ. 서론 15
Ⅱ. 문헌고찰 18
1. Influence of seaweed intake on inflammation and inflammation-related diseases 18
2. Polygenic risk scores of inflammation 19
3. Interactions of dietary factor and genetic risk score in inflammation 20
Ⅲ. 연구대상 및 방법 22
1. 연구대상 및 데이터 22
2. 염증 수치의 평가 24
3. 식이평가 24
4. 공변량 25
5. 유전자형 분석 26
6. 다유전자 위험 점수(PRS) 구축 29
7. 통계분석 30
Ⅳ. 연구결과 31
1. General characteristics of study participants according to hs-CRP level 31
2. General characteristics of the study participants based on genetic variation 34
3. Association between laver, kelp/sea mustard, total seaweed intake with high-sensitivity C-reactive protein level (hs-CRP) using Log-transformation and using linear regression analysis 37
4. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high hs-CRP level (〉1mg/L) incidence depending on laver intake by sex 39
5. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high hs-CRP level (〉1mg/L) incidence depending on kelp/sea mustard intake by sex 41
6. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high hs-CRP level (〉1mg/L) incidence depending on total seaweed intake by sex 43
7. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high hs-CRP level (〉1mg/L) incidence depending on polygenic risk score by sex 45
8. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high-sensitivity C-reactive protein level (hs-CRP〉1mg/L) incidence depending on polygenetic risk score by laver, kelp/sea mustard, total seaweed intake 47
Ⅴ. 고찰 49
Ⅵ. 결론 55
References 56
Abstract 60
Table 1. 31 Single nucleotide polymorphisms (SNPs) characteristic of genetic the related to high-sensitivity C-reactive protein (hs-CRP) levels in korean adults 28
Table 2. General characteristics of study participants according to hs-CRP level 32
Table 3. General characteristics of the study participants based on genetic variation 35
Table 4. Association between laver, kelp/sea mustard, total seaweed intake with high-sensitivity C-reactive protein level (hs-CRP) using Log-transformation and using linear regression analysis 38
Table 5. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high hs-CRP level (〉1mg/L) incidence depending on laver intake by sex 40
Table 6. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high hs-CRP level (〉1mg/L) incidence depending on kelp/sea mustard intake by sex 42
Table 7. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high hs-CRP level (〉1mg/L) incidence depending on total seaweed intake by sex 44
Table 8. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high hs-CRP level (〉1mg/L) incidence depending on polygenic risk score by sex 46
Table 9. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of high-sensitivity C-reactive protein level (hs-CRP〉1mg/L) incidence depending on polygenetic risk score by laver, kelp/sea mustard, total seaweed intake 48
Figure 1. Flow chart of the study design 23
Figure 2. Study design to generate polygenic risk score (PRS) associated with hs-CRP interaction SNP 29