Title Page
ABSTRACT
Contents
1. INTRODUCTION 10
2. MATERIALS AND METHODS 13
2.1. Data source 13
2.2. Hi-C Data Processing 13
2.3. Haplotype Phasing 13
2.4. Differential chromatin interaction analysis 14
2.5. Topologically associated domain analysis 15
3. RESULTS 16
3.1. Haplotype phasing of the K562 cell line Hi-C data. 16
3.2. Reconstruction of The Philadelphia chromosome using Hi-C phasing. 17
3.3. Differential chromatin interaction analysis with the normal chromosome and the Philadelphia chromosome within transcription start sites in chromosome 9 and 22. 18
3.4. Comparison of differentially interacting chromatin between the normal chromosome and the Philadelphia chromosome within topologically associating domains (TADs). 19
4. DISCUSSION 28
5. REFERENCES 30
국문 초록 33
Table 3.1. Haplotype phasing results of SRR1658693 sample. 22
Table 3.2. Haplotype phasing results of SRR1658694 sample. 23
Figure 1. Haplotype phasing of the K562 cell line Hi-C data. 20
Figure 2. Reconstruction of the Philadelphia chromosome using Hi-C phasing. 24
Figure 3. Differential chromatin interaction analysis with the normal chromosome and the Philadelphia chromosome within transcription start sites of genes in chromosome 9 and 22. 26
Figure 4. Differential TAD configurations between the normal chromosome and the Philadelphia chromosome within tumor-related genes (ABL1 and HIC2) with differential... 27