표제지
목차
국문요약 8
서론 11
재료 및 연구 방법 14
1. 연구기간과 대상 14
1) SFTS 환자군 14
2) Scrub typhus 환자군 15
3) 건강한 대조군(Healthy controls) 15
2. 사이토카인 분석 16
3. 통계학적 분석 17
결과 18
1. SFTS 환자와 쯔쯔가무시병 환자의 급성기 사이토카인과 케모카인 비교 18
2. 쯔쯔가무시병 환자에서 중증도에 따른 급성기 사이토카인과 케모카인 비교 26
3. 쯔쯔가무시병 환자에서 시간에 따른 사이토카인과 케모카인의 변화 분석 31
4. 쯔쯔가무시병 환자에서 급성기와 회복기의 사이토카인과 케모카인 비교 34
5. SFTS 환자에서 사이토카인과 케모카인의 분석 36
고찰 44
참고문헌 49
영문요약 55
Table 1. Baseline characteristics of SFTS and scrub typhus patients. 20
Table 2. Baseline characteristics of scrub typhus patients. 27
Table 3. The Sequential Organ Failure Assessment (SOFA) Score 29
Figure 1. Flow chart for patients included in the comparison between SFTS and scrub typhus. 22
Figure 2. Cytokine and chemokine levels that were comparable between SFTS and scrub typhus. 23
Figure 3. Cytokines levels that were highest in SFTS patients. 24
Figure 4. Cytokines that scrub typhus showed different pattern from SFTS and healthy control. 25
Figure 5. Comparison of the cytokines and chemokines in serum of patients with scrub typhus between those with high SOFA score and low SOFA score. 30
Figure 6. Time kinetics of the cytokines and chemokines in serum of patients with scrub typhus after admission. 33
Figure 7. Comparison of the cytokines and chemokines in serum of patients with scrub typhus between the acute and recovery phases. 35
Figure 8. Comparison of cytokines and chemokines in serum of survivors and non-survivors among patients with SFTS. 38
Figure 9. Plasma concentration of cytokines and chemokines in serum of survivors and non-survivors among patients with SFTS. 40
Figure 10. Time kinetics of the cytokines and chemokines in serum of patients with SFTS after admission. 43