Title Page
Abstract
Abbreviations
Contents
Chapter 1. Machine learning models to predict the warfarin discharge dosage using clinical information of East Asian inpatients 8
Abstract 8
1. Introduction 9
2. Methods 9
2.1. Study Design 9
2.2. Data collection 10
2.3. Data Preparation 11
2.4. Model Development and Validation 12
2.5. Performance Metrics 13
2.6. Model Interpretations 13
2.7. Comparison of Models' and Physicians' Predictions 13
3. Results 14
3.1. Patient Characteristics 14
3.2. Model Performance 15
3.3. Model Interpretations 15
3.4. Comparison of Models' and Physicians' Predictions 18
4. Discussion 19
Chapter 2. Database integrated between EMR (Electronics Medical Record) and Open Targets Platform for pharmacogenomic study 20
Abstract 20
1. Introduction 21
2. Methods 22
2.1. Data source: Open Targets Platform 22
2.2. Cohort extraction: AMC EMRs 22
2.3. Integration between EMR and open targets platform 22
3. Results 22
4. Discussion 26
Conclusion 26
Reference 27
Appendix 32
국문 요약 36