Title Page
Abstract
Contents
Introduction 9
Materials and methods 10
Results 13
Discussion 19
References 22
국문요약 25
Table 1. Clinicopathological features of the 366 gastric cancer patients with complete NGS. 13
Table 2. Response to platinum-based chemotherapy according to pBRCA mutation in tumor tissue 14
Table 3. Molecular classification of enrolled gastric cancer. 18
Table 4. Response to platinum-based chemotherapy according to pBRCA mutation and MSS in tumor tissue 21
Figure 1. Patient selection process 10
Figure 2. Survival rate according to pBRCA mutation status 15
Figure 3. Details of pBRCA mutations. 16
Figure 4. Genomic landscape of selected gastric cancer samples. 17
Figure 5. Comparison of copy number and tumor mutation burden. 18