Title Page
Abstract
Contents
Introduction 8
Materials and methods 10
Patient selection and clinical parameters 10
Morphological analysis 10
Immunophenotypic evaluation 12
Fluorescence in situ hybridization (FISH) analysis 12
Targeted NGS 13
Statistical analysis 13
Ethical statement 14
Results 15
Baseline characteristics of all patients 15
Morphologic analyses 15
Clinicopathological and immunophenotypic parameters associated with SSP 17
FISH analyses 19
Targeted NGS analyses according to SSP 19
Survival analysis of morphologic features in double expressor lymphoma 20
Discussion 24
Conclusion 27
References 28
Supplementary Appendix 32
국문요약 38
Table 1. Baseline characteristics of the enrolled patients 16
Table 2. Comparison of clinicopathologic parameters between the SSP and non-SSP groups 18
Table 3. Univariate and multivariate Cox proportional hazard analysis for overall survival and progression-free survival 23
Figure 1. Representative image for SSP and DEL. (A) Tingible body macrophages in the background of tumor cells are notable features of SSP (hematoxylin & eosin [H&E], x200);... 11
Figure 2. Targeted NGS analysis of 22 DEL cases. 20
Figure 3. (A-B) Kaplan-Meier survival curves for (A) OS and (B) PFS show a significantly shorter PFS for the SSP group than that for the non-SSP group. The OS of the SSP group was... 21