표제지
초록
ABSTRACT
목차
1장 서론 14
2장 재료 및 방법 17
2.1. Vitamin C 수용액 18
2.2. Vitamin C의 구형 과립화 18
2.3. 반응표면분석법(RSM)을 이용한 실험설계 21
2.4. RSM에 의한 vitamin C의 구형 과립 조건의 최적화 23
2.5. HPLC vitamin C 구형 과립의 함량분석 24
2.6. Vitamin C 구형 과립의 수율 25
2.7. Vitamin C 구형 과립의 입도분석 25
2.8. Vitamin C 구형 과립의 형태학적 관찰 26
2.9. 비표면적측정 26
2.10. 수분 흡착 및 탈착 특성 28
2.11. 통계분석 28
3장 결과 및 고찰 29
3.1. Vitamin C 구형 과립의 최적조건 수립 29
3.1.1. RSM에 의한 vitamin C 구형 과립의 최적조건 수립 및 특성 29
3.1.2. Vitamin C 구형 과립의 최적조건 모형 잔차분석 35
3.1.3. Vitamin C 구형 과립의 공정 최적화 37
3.2. Vitamin C 구형 과립 제조 및 최적조건의 재현성 39
3.3. Vitamin C구형 과립의 함량 분석 41
3.4. Vitamin C 구형 과립의 입도분석 43
3.5. 전자현미경(SEM)을 이용한 vitamin C 구형 과립의 형태학적 관찰 45
3.6. N₂ gas 흡착에 의한 vitamin C 구형 과립의 비표면적 특성 48
3.7. Vitamin C 구형 과립의 수분 흡착 및 탈착 특성 56
4장 결론 61
참고문헌 63
Table 1. Coded levels for independent variables for vitamin C spherical granules 22
Table 2. Faced central composite design (FCCD) for vitamin C spherical granules by response surface methodology 30
Table 3. Values of regression coefficients calculated for spherical granules of vitamin C 32
Table 4. Vitamin C assay by response surface methodology 42
Table 5. Surface analysis of vitamin C granules made by fluidized bed coating method 55
Fig. 1. Manufacturing process diagram of vitamin C spherical granules. 20
Fig. 2. Contour and 3-D response surface plots of vitamin C spherical granules. Contour plot of air flow rate and product temperature effect in spherical granules yield (A), 3-D response surface plot of air flow rate and product temperature effect in... 34
Fig. 3. Residual plots of model for error values. Normal probability plot of the residuals (A), residual versus fits (B), and residual versus order (C). 36
Fig. 4. Optimization curve for manufacturing of vitamin C spherical granules. 38
Fig. 5. Photograph of vitamin C spherical granules made with the optimal condition by response surface methodology. 40
Fig. 6. Particle size distribution of vitamin C spherical granules. 44
Fig. 7. Scanning electron microscopic images of vitamin C granules made by fluidized bed coating method. (A) ×150, (B) ×500, (C) ×1,000, and (D)... 47
Fig. 8. BET-isotherm plot of vitamin C granules made by fluidized bed coating method 49
Fig. 9. International Union of Pure and Applied Chemistry (IUPAC) classification of adsorption isotherms. 50
Fig. 10. The four hysteresis shapes of adsorption isotherm found by nitrogen adsorption 52
Fig. 11. BET transform plots for adsorption isotherm of vitamin C granules made by fluidized bed coating method. 53
Fig. 12. Mass change of vitamin C spherical granules prepared by fluidized bed process during moisture sorption and desorption from 0 to 90% relative humidity. 58
Fig. 13. Moisture sorption and desorption behavior of vitamin C spherical granules prepared by fluidized bed process from 0 to 90% relative humidity. 59
Fig. 14. Five types of van der Waals adsorption isotherm P: water vapor pressure of food in arbitrary temperature... 60