Title Page
Contents
ABSTRACT 6
Ⅰ. Introduction 8
Ⅱ. Material and Methods 11
Ⅲ. Results 19
Ⅳ. Discussion 40
Ⅴ. Conclusions 43
Ⅵ. References 44
국문초록 46
Figure 1. Animal experiment scheme and effects of PG on DNCB-induced skin in NC/Nga mice 20
Figure 2. Effects of PG on the epidermal and ear skin thickness in DNCB-induced NC/Nga mice. 22
Figure 3. Effects of PG on inflammatory cytokine, iNOS, in DNCB-induced AD skin lesions in NC/Nga mice 24
Figure 4. Effects of PG on HaCaT keratinocytes cell viability 26
Figure 5. Effects of PG on AD-related cytokines, TNF-α, in HaCaT keratinocytes which were stimulated with TNF-α and IFN-γ 28
Figure 6. Effects of PG on AD-related cytokines, IL-6, in HaCaT keratinocytes which were stimulated with TNF-α and IFN-γ 30
Figure 7. Effects of PG on AD-related cytokines, IL-1β, in HaCaT keratinocytes which were stimulated with TNF-α and IFN-γ 32
Figure 8. Effects of PG on RAW264.7 macrophages cell viability 35
Figure 9. Effects of PG on inhibition of NO production in LPS-stimulated RAW 264.7 macrophages. 37
Figure 10. Effects of PG on inflammatory cytokine iNOS in LPS-stimulated RAW 264.7 macrophages. 39