Title Page
Contents
Abstract 8
Background 10
Materials and Methods 11
Results 16
Discussion 18
Conclusion 25
References 45
국문 초록 52
Table 1. Characteristics of R-CHOP treated DLBCL patients according to reimbursement of primary prophylaxis (n=6616). 27
Table 2. Comparison of FN-related hospitalizations and overall survival, regardless of primary prophylaxis. 28
Supplementary Table S1. Characteristics of patients with R-CHOP treated DLBCL from 2014 to 2016 (n=5710). 31
Supplementary Table S2. Comparison of FN-related hospitalizations with and without primary prophylaxis. 33
Supplementary Table S3. Comparison of overall survival with and without primary prophylaxis. 34
Supplementary Table S4. Comparison of hospital stays with and without primary prophylaxis. 36
Supplementary Table S5. Comparison of medical costs and ER visits with antibiotic use, with and without primary prophylaxis. 37
Supplementary Table S6. Comparison of therapeutic G-CSF use 38
Supplementary Table S7. Characteristics of R-CHOP treated DLBCL patients from 2010 to 2016 (n=11,491). 39
Figure 1. Comparison of FN-related hospitalization and overall survival according to reimbursement for primary prophylaxis presented as... 29
Figure 2. Comparison of hospital stays according to reimbursement for primary prophylaxis (July 2011-June 2013 vs. January... 30
Supplementary Figure S1. Comparison of FN-related hospitalization and overall survival according to reimbursement for primary prophylaxis presented as forest... 42
Supplementary Figure S2. Survival probability of primary and secondary prophylaxis using the Cox regression model (July 2011-June 2013 vs. January... 43
Supplementary Figure S3. Survival probability of primary and secondary prophylaxis using the Cox regression model (from 2014 to 2016, n=5710, not... 44