표제지
목차
요약 8
1. 서론 10
2. 재료 및 방법 13
2.1. 항균필름의 특성 13
2.2. 표면손상(aging): 물리적 및 광학적 풍화 15
2.3. 인체 모사액: 인공땀과 인공피지 17
2.4. 용출시험 및 Wipe sampling 방법 20
2.5. 인체 위해성 평가 22
3. 결과 및 고찰 25
3.1. 항균필름의 중금속 총 함량 25
3.2. 두 가지 시험법(용출시험, 와이프 샘플링)에 대한 전이량 평가 27
3.3. 인공피지 유무에 따른 전이량 평가 31
3.4. 표면손상(aging) 된 시료의 전이량 평가 33
3.5. Monte carlo simulation을 적용한 인체 위해성 평가 38
4. 결론 41
5. 참고문헌 43
6. 부록 56
Abstract 57
Table 1. 11 types of antibacterial films used in this study 14
Table 2. Composition of two artificial sebum formulations used in dermal migration 18
Table 3. Dermal exposure parameters used in risk assessment 24
Table 4. Material and total concentration of Ag, Cu, and Zn (mg/kg ± standard deviation) and migration rate (%) of antibacterial films 26
Table 5. Dermal migration for Cu and Zn (mg/kg ± standard deviation) of antibacterial films for two artificial sweat 28
Table 6. Dermal migration for Cu and Zn of antibacterial films without or with artificial sebum T-test results 31
Table 7. XPS analysis result before and after UVC test of antibacterial film 37
Table 8. Mean, standard deviation and 95th percentile in figure 14 39
Fig. 1. Rubbing tester of physical weathering. 16
Fig. 2. UVC tester of optical weathering. 16
Fig. 3. Sebum test procedure schematic diagram. 19
Fig. 4. Preparation and extraction of antibacterial film samples. 21
Fig. 5. The process of wiping the surface of the antibacterial film in an S pattern. 21
Fig. 6. Dermal migration for Cu and Zn concentrations evaluated by the dissolution test method and the wipe sampling method for the... 30
Fig. 7. Dermal migration for Cu and Zn of antibacterial films without or with artificial sebum. 32
Fig. 8. Dermal migration according to physical weathering. 33
Fig. 9. Dermal migration according to optical weathering. 34
Fig. 10. FE-SEM analysis result of antibacterial film surface raw sample (a), UVC test (b). 35
Fig. 11. FTIR analysis result before and after UVC test of antibacterial film. 36
Fig. 12. Hazard quotient (HQ) results for children and adults. 39
Fig. 13. Sensitivity analysis results of children and adults. 40