Title Page
Contents
ABBREVIATION LISTS 4
EQUIPMENT LISTS 6
Ⅰ. INTRODUCTION 7
Ⅱ. MATERIALS AND METHODS 10
Ⅱ. 1. Experimental Animals and husbandry. 10
Ⅱ. 2. Test articles. 10
Ⅱ. 3. Groupings and administration. 11
Ⅱ. 4. Observation of clinical signs. 12
Ⅱ. 5. Changes of body weights. 12
Ⅱ. 6. Food consumption measurements 12
Ⅱ. 7. Water consumption measurements 12
Ⅱ. 8. Fecal excretion consumption measurements 12
Ⅱ. 9. Urine excretion consumption measurements 13
Ⅱ. 10. Hematology 13
Ⅱ. 11. Serum biochemistry 13
Ⅱ. 12. Necropsy 14
Ⅱ. 13. Organ Weights 14
Ⅱ. 14. Histopathology 15
Ⅱ. 15. Statistical analyses 16
Ⅲ. RESULTS 17
Ⅲ. 1. Mortalities 17
Ⅲ. 2. Clinical signs 17
Ⅲ. 3. Changes on body weights and gains 17
Ⅲ. 4. Changes on food consumptions 17
Ⅲ. 5. Changes on water consumptions 17
Ⅲ. 6. Changes on fecal excretions 17
Ⅲ. 7. Changes on urine excretions 17
Ⅲ. 8. Changes on the organ weights 18
Ⅲ. 9. Hematology 18
Ⅲ. 10. Serum biochemistry 18
Ⅲ. 11. Necropsy findings 18
Ⅲ. 12. Histopathological findings 18
Ⅲ. 13. MTD, NOAEL and target organs 18
Ⅳ. DISCUSSION 56
Ⅴ. Abstract 59
Ⅵ. REFERENCES 61
Ⅶ. 초록 64
APPENDICES 66
APPENDIX 1. Mortalities and Clinical Signs (Incidences, Individual Data) 66
APPENDIX 2. Body Weight (g, Individual Data) 82
APPENDIX 3. Food Consumptions (g/24 hrs/rat, Individual Data) 102
APPENDIX 4. Water Consumptions (ml/24 hrs/rat, Individual Data) 105
APPENDIX 5. Fecal Excretion (g/24 hrs/rat, Individual Data) 108
APPENDIX 6. Urine Excretion (ml/24 hrs/rat. Individual Data) 111
APPENDIX 7. Absolute Organ Weight (g, Individual Data) 114
APPENDIX 8. Relative Organ Weight (% of body weights, Individual Data) 122
APPENDIX 9. Hematological Values (Individual Data) 130
APPENDIX 10. Serum Biochemistrical Values (Individual Data) 138
APPENDIX 11. Necropsy Findings - Gross Findings (Incidences, Individual Data) 146
APPENDIX 12. Histological Findings - Microscopic Findings (Incidences, Individual Data) 154
ANNEX 1. Animal Specification of SPF/VAF Outbred Crl:CD [Sprague-Dawley] Rats Supplied by OrientBio (Seungnam. Korea) 162
ANNEX 2. Health Monitoring Reports of SPF/VAF Outbred Crl:CD [Sprague-Dawley] Rats Supplied by OrientBio (Seungnam, Korea) 163
ANNEX 3. Certification of Approval of Animal Experiment by the Institutional Animal Care and Use Committee in Daegu Haany University (Gyeongsan, Korea) 164