Title Page

ABSTRACT

Contents

Chapter 1. Introduction 11

1.1. Research Background and Related Research Trends 11

1.1.1. Development of wearable temperature measurement and treatment healthcare technology 11

Chapter 2. Investigating temperature monitoring and thermal therapy on a large specific skin area with Graphene-based multifunctional and wearable thermal patch 13

2.1. Material and Method 13

2.1.1. Fabrication of graphene-based capacitive sensor array 13

2.1.2. Evaluation of graphene-based capacitive sensor array 15

2.1.3. Experimental renal infarction 16

2.1.4. Wound creation 17

2.2. Result 18

2.2.1. Wearable wireless graphene based biomedical patch system 18

2.2.2. Function tests of capacitive temperature sensor patch 25

2.2.3. Performance tests of temperature sensor array 29

2.2.4. Practical application wearable temperature sensor 32

2.2.5. Diagnosis of renal infarction and thermal therapy of skin wounds using a graphene based medical patch 36

2.3. Discussion 42

References 43

국문초록 47

Table S.1. Comparison of previous flexible temperature sensors with the devices in this work 24

Fig. 1. Biomedical patch for temperature monitoring and heating. 21

Fig. 2. Functional demonstrations of capacitive temperature sensor patch. 27

Fig. 3. Performance of temperature sensor array. 30

Fig. 4. Practical applications of skin-mounted temperature sensor. 34

Fig. 5. Animal experiment for diagnosis of diseases and heat treatment. 38

Fig. S1. Evaluation of spatial resolution in sensor design and measurement. 31

Fig. S2. Modulation of capacitive sensor by concentration of Al2O3/SU-8 composite 5 wt%/10 wt%/15 wt%. 22

Fig. S3. Stability test of capacitive temperature sensor. 22

Fig. S4. Optical image and circuit design of FPCB for wireless system. 23

Fig. S5. Block-diagram for multiplexed sensor array (8 '8 channel) measurement system. 23

Fig. S6. Enlarged graph of Fig. 3B which shows the thermal response time of the sensor. 28

Fig. S7. Enhancement of temperature sensing sensitivity using heater calibration process. 28

Fig. S8. Evaluations of temperature mapping during sleep. 35

Fig. S9. Animal experiments for detecting infarction by temperature mapping. 39

Fig. S10. Optical images of wound region on three kinds of groups (control group, W/O GH group and GH group) during 10 days. Each group consisted of 5 rats. 40

Fig. S11. Comparison of the wound size quantified by area over 10 days for three different groups (control group, W/O GH group and GH group). 41

Fig. S12. Fabrication process of the capacitive temperature sensor array and heater. 14