Title Page
국문요약
Contents
INTRODUCTION 8
METHODS 8
RESULTS 10
DISCUSSION 12
Conclusion 14
References 14
Abstract 16
Figure 1. Flow charts of the traumatic brain injury (TBI) model validation experiment (A) and the experiment assessing the effects of anti-inflammatory therapies on secondary injury (B). 17
Figure 2. Confirmation of the injury site and histopathological analyses of injury severity. (A) The injury site at the cortical midpoint following weight drop was confirmed by the presence of local... 18
Figure 3. Changes in body and brain weight among mice subjected to traumatic brain injury (TBI), sham TBI (left panels), or TBI followed by vehicle or anti-inflammatory treatment (right panels). 19
Figure 4. Brain expression of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10 in the traumatic brain injury (TBI) model mice after early treatment with vehicle (phosphate-buffered... 20
Figure 5. Expression of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-10 in the draining lymph nodes of traumatic brain injury (TBI) model mice after early treatment with vehicle... 21
Figure 6. Histopathological findings in the brains of traumatic brain injury (TBI) model mice as quantified using QuPath software after early treatment with vehicle (phosphate-buffered saline) or an... 22