Title Page
Abstract
Contents
1. INTRODUCTION 8
1.1. Schizophrenia and structural brain alterations 8
1.2. Cerebral gray matter volume and cortical thickness alterations in schizophrenia 9
1.3. Brain lateralization in normal population 10
1.4. Failure of normal brain lateralization in schizophrenia 11
1.5. Necessity for multicenter data analysis and ComBat harmonization 12
1.6. The aim of the study 13
2. MATERIALS AND METHODS 14
2.1. Participants and imaging 14
2.1.1. Asan medical center (AMC) 14
2.1.2. Jeonbuk National University Hospital (JBUH) 15
2.1.3. University of California Los Angeles Consortium for Neuropsychiatric Phenomic LA5c Study (UCLA) 15
2.1.4. Neuromorphometry by Computer Algorithm Chicago (NMorphCH) and Center of Biomedical Research Excellence (COBRE) 16
2.2. Image acquisition 16
2.3. Image processing and cortical and subcortical measurements using FreeSurfer 17
2.4. Harmonization of multi-site MRI imaging with ComBat 20
2.5. Laterality of cerebral brain volumes and cortical thickness 20
2.6. Correlation with clinical variables 21
2.7. Statistical analysis 22
3. RESULTS 23
4. DISCUSSION 50
5. CONCLUSIONS 58
6. REFERENCES 59
국문 요약 66