Title Page
ABSTRACT
Contents
Introduction 8
Materials and methods 9
Study design and clinical variables 9
Outcome definition and treatment 10
Imaging data 11
Definitions of subventricular zone distance (SVD) 12
Clinico-pathologic variables in RTOG nomogram 13
Statistical analysis 14
Performance measurement 15
Results 16
Clinical characteristics of the patients 16
Reproducibility of the SVD 16
Association between SVD and survival 17
Multivariable survival model including SVD 18
Comparison of survival performance between the SVD-updated model and RTOG model 18
Discussion 19
Conclusion 23
참고문헌 34
논문요약 37
부록 39
Table 1. Baseline clinical characteristics of the study patients 24
Table 2. Associations between subventricular zone distance and overall survival in the training set 25
Table 3. Updated survival model with subventricular zone involvement applied to the validation set 26
Table 4. Time-dependent discrimination measures for death up to 3 years 27
Figure 1. Flow diagram of patient inclusion and exclusion 28
Figure 2. Definition of subventricular zone distance (SVD) 29
Figure 3A. Kaplan-Meier survival curves from the training and validation sets, stratified according to definition 1 (edge to subventricular zone) 30
Figure 3B. Nomogram for the SVD-updated model 31
Figure 4. Representative images from patients whose survival was well predicted by the updated SVD model 32