표제지
목차
國文要略 10
제1장 서론 12
1.1. 연구개요 12
1.2. 연구의 목적 및 의의 14
1.3. 연구의 범위 및 방법 15
제2장 이론 및 기술배경 16
2.1. CNT/Silicone 합성물 16
2.2. CNT/Silicone 합성물 CNT 분산 18
2.3. 식약처 의료기기 기준 20
제3장 실험 및 고찰 22
3.1. 탄소나노튜브/실리콘 전도성 복합체 분석 22
3.1.1. 표면 분석 22
3.1.2. 전도성 테스트 24
3.1.3. 표면저항 분석 26
3.1.4. 기계적 물성 테스트 28
3.1.5. 세포 독성 평가 30
3.1.6. 휘발성 유기화합물 정량 평가 36
3.2. 안구건조증 치료기기 전극 성능 평가 39
3.2.1. 미세전류/온열 자극에 따른 세포 안전성 시험 39
3.2.2. 미세전류/온열 자극의 효능 평가 연구 44
3.2.3. 발열 온도 편차 시험 50
3.2.4. 원적외선 방사율 측정 52
3.2.5. 최대전류밀도 측정 53
제4장 결론 54
References 56
Abstract 59
Table 1. Item description of personal infrared radiators 20
Table 2. Surface resistance measurement result 27
Table 3. Raw data of mechanical property test 29
Table 4. Five test materials for cytotoxicity evaluation 30
Table 5. Cytotoxicity assessment survival rate of HaCaT cells 32
Table 6. Cytotoxicity evaluation of NHEKs cells survival rate 34
Table 7. TD-GC/MS analysis data of carbon nanotube/silicone composite 37
Table 8. Tear secretion measurement results before and after treatment in normal old rabbits applied with microcurrent, radiant heat... 45
Table 9. Tear film break-up time results before and after treatment in normal old rabbits applied with microcurrent, radiant heat and... 47
Table 10. Raw data of fever temperature measurement at 3.4V voltage 51
Fig. 1. Cross-sectional analysis of conductive composites (a) chemical dispersion, (b) blending, (c) physical dispersion 22
Fig. 2. Surface analysis of conductive composites (a) chemical dispersion, (b) blending, (c) physical dispersion 23
Fig. 3. Conductivity test of carbon nanotube/silicone conductive composite 24
Fig. 4. Surface resistance measurement specimen 26
Fig. 5. ASTM D412 Type D standard 28
Fig. 6. Graph of mechanical property test 28
Fig. 7. Preparation process for cell processing of 5 materials 31
Fig. 8. Formazan formation after MTT/DMSO treatment ; MTT assay 32
Fig. 9. Cytotoxicity assessment viability in HaCaT cells 33
Fig. 10. Cytotoxicity assessment viability in NHEKs cells 34
Fig. 11. TD-GC/MS analysis results 38
Fig. 12. Cell safety test device (a) heating pad and controller, (b) microcurrent pad and controller 39
Fig. 13. Fluorescent microscope image after radiant heat and microcurrent irradiation (x10) 41
Fig. 14. Fluorescent microscopy image of live and dead cells of conjunctival epithelial cells (hCjECs) immediately after radiant... 42
Fig. 15. Fluorescence microscopy images of live and dead cells of conjunctival epithelial cells (hCjECs) after 48 hours of... 43
Fig. 16. Tear secretion measurement results before and after treatment in normal old rabbits applied with microcurrent, radiant heat... 46
Fig. 17. Tear film break-up time results before and after treatment in normal old rabbits applied with microcurrent, Radiant heat and... 47
Fig. 18. Meibography scan result before/after treatment 48
Fig. 19. Slit lamp microscopic observation results before and after treatment 49
Fig. 20. Conductive pad heating temperature deviation measurement test result 50