Title Page
Contents
ABBREVIATIONS 12
1. INTRODUCTION 14
2. MATERIALS AND METHODS 16
2.1. Study population 16
2.2. Definition of dyslipidemia 17
2.3. Clinical and biochemical assessments 19
2.4. SNP genotyping 21
2.5. Statistical analysis 23
3. RESULTS 24
3.1. Clinical characteristics according to the presence of dyslipidemia 24
3.2. Clinical characteristics according to the NPC1L1 rs217434 genotype 26
3.3. Associations between the NPC1L1 rs217434 genotype and dyslipidemia 28
3.4. Association of TC, LDL-C, hs-CRP, and 8-epi-PGF₂α with the NPC1L1 rs217434 A〉G polymorphism[이미지참조] 32
4. DISCUSSIONS 35
5. CONCLUSION 41
6. REFERENCES 42
ABSTRACT 50
국문요약 52
Table 1. Biochemical and clinical characteristics of the normal and dyslipidemia groups 25
Table 2. Biochemical and clinical characteristics of individuals according to the NPC1L1 rs217434 genotype 27
Table 3. Overall differences in biochemical and clinical characteristics among individuals according to the presence of dyslipidemia and the NPC1L1 rs217434 genotype 30
Figure 1. Flow chart of the study 18
Figure 2. Associations of TC, LDL-C, hs-CRP and 8-epi-PGF₂α with the NPC1L1 rs217434 A〉G polymorphism[이미지참조] 34