표제지
목차
국문요약 7
Abstract 8
I. 서론 10
II. 본론 14
1. 연구대상 (Participants) 14
2. 자기공명영상 (MRI) 획득 15
3. 자기공명영상의 처리 16
가. pBrain 영상처리 16
나. Voxel based morphometry 와 Surface-based morphometry 19
다. 통계처리 20
III. 결과 21
1. 대상자의 특성 (Characteristics of the participants) 21
2. pBrain의 부피 측정 23
3. Voxel based morphometry and Surface based morphometry 25
IV. 토의 33
참고문헌 37
Table 1. Demographic and clinical data for patients with major depressive disorder and healthy controls. 22
Table 2. Results of MRI volumetry. 23
Table 3. Reduced sulcal depth in patients with depression 26
Table 4. Comparisons between normal controls and MDD patients with surface-based morphometry (SBM) 31
Supplementary 1. Full name description of FreeSurfer's codes 46
Figure 1. T1 (left) and T2 (right) brain MRI scanned by 3T Prisma MRI scanner. 16
Figure 2. The schematic pBrain pipeline. T2 images of all subjects were denoised, registered to MNI152 space, intensity inhomogeneity was... 17
Figure 3. Automatically labelled subcortical areas by pBrain. Two dimensional view of labelling of substantia nigra (SN, left: green, right:... 18
Figure 4. Three dimension view of labelling of substantia nigra (SN, left: green, right: sky blue), red nucleus (RN, left: red, right: yellow) and... 18
Figure 5. Box and whisker plots of red nucleus, substantia nigra, and subthalamic nucleus. Left subthalamic nucleus of MDD was significantly increased compared to normal controls' left... 24
Figure 6. Reduced sulcal depth in MDD patients. Sulcal depths of MDD were reduced compared to the normal controls in the left hemisphere of... 27
Figure 7. Box and whisker plots of significantly reduced sulcal depth in depressed patients. Left posterior ramus of the lateral sulcus... 29
Figure 8. The correlation between the sulcal depth and Hamilton Rating Scale for Depression (HDRS) score. Sulcal depths of MDD were... 30
Figure 9. Reduced fractal dimension in MDD patients. Fractal dimension of MDD were reduced compared to the normal controls in the right... 31
Figure 10. Increased fractal dimension in MDD patients. Fractal dimension of MDD were increased compared to the normal controls in the right hemisphere... 32
Figure 11. Reduced gyrification index in MDD patients. Gyrification index of MDD were reduced compared to the normal controls in the right... 32
Figure 12. Increased cortical thickness in MDD patients. Cortical thickness of MDD were increased compared to the normal controls in the left hemisphere... 33