Title Page
Contents
List of Abbreviations 8
Abstract 9
Chapter I. Mediatory role of BLT2 in the lung inflammation in CLP-induced sepsis 12
1. Abstract 14
2. Introduction 15
3. Materials and Methods 17
4. Results 20
5. Discussion 30
6. References 33
Chapter II. Mediatory role of BLT2 in House Dust Mites-induced eosinophilic lung inflammation 37
1. Abstract 39
2. Introduction 40
3. Materials and Methods 42
4. Results 44
5. Discussion 52
6. References 55
Chapter III. Mediatory role of BLT2 in LPS/OVA-induced neutrophilic lung inflammation via regulation of G-CSF production 60
1. Abstract 62
2. Introduction 63
3. Materials and Methods 65
4. Results 69
5. Discussion 84
6. References 88
Conclusion 93
Abstract in Korean 95
Figure 1. The levels of BLT2 and its ligands are highly elevated in CLP-induced sepsis. 22
Figure 2. BLT2 is critical for the synthesis of sepsis-associated inflammatory cytokines in CLP-induced sepsis. 24
Figure 3. BLT2 regulates NF-κB activation in the lungs of mice with CLP-induced sepsis. 26
Figure 4. Lung inflammation is suppressed by BLT2 blockade in CLP-induced sepsis. 29
Figure 5. HDM-induced TH2 cytokine synthesis is dependent on BLT1 and BLT2[이미지참조] 45
Figure 6. BLT1 and BLT2 contribute to HDM-induced eosinophilic airway inflammation. 47
Figure 7. 5-/12-lipoxygeneases play roles in HDM-induced TH2 cytokine synthesis.[이미지참조] 49
Figure 8. HDM-induced eosinophilic airway inflammation is suppressed by 5-/12-LO inhibition. 51
Figure 9. Elevated levels of G-CSF in the steroid-resistant neutrophilic lung airway inflammation model. 71
Figure 10. G-CSF is critical for neutrophilic airway inflammation. 74
Figure 11. BLT2 mediates the production of G-CSF in neutrophilic airway inflammation. 77
Figure 12. BLT2 knockout attenuates both G-CSF production and neutrophilic airway inflammation. 80
Figure 13. 12-LO is also necessary for the production of G-CSF and contributes to neutrophilic airway inflammation. 83
Figure 14. The proposed scheme of the 12-LO-BLT2-G-CSF cascade in LPS/OVA-induced steroid-resistant neutrophilic airway inflammation. 87
Figure 15. Scheme for the mediatory role of BLT2 in lung inflammation. 94