Title Page

Contents

Abstract 9

Chapter 1. INTRODUCTION 11

Chapter 2. Methods 14

2.1. Data source 14

2.2. Study Population 15

2.3. Measurements 16

2.4. Statistical Analysis 17

Chapter 3. Results 18

3.1. Study flow 18

3.2. Characteristics of study population 19

3.3. Comparison of Cognitive function 22

Chapter 4. Discussion 30

References 32

논문요약 34

Table 1. Participant characteristics (N＝1,190) 20

Table 2-1. Mean and regression coefficients of subjective memory scores between treatment group using SMCQ (N＝1,190) 24

Table 2-2. Mean and regression coefficients of cognitive function scores between treatment group using EORTC-QLQ-C30 (Cognitive Function) (N＝1,190) 25

Table 3-1. Means and regression coefficients of subjective memory scores in the ovarian function suppression injection group using SMCQ (N＝774) 28

Table 3-2. Means and regression coefficients of subjective memory scores in the ovarian function suppression injection group using EORTC-QLQ-C30 (Cognitive Function) (N＝744) 29

Figure 1. Flow chart 18

Figure 2. Subgroup analysis (Socio-demographic factors) 26

Figure 3. Subgroup analysis (clinical factors) 27