Title Page
Contents
ABBREVIATIONS 12
1. INTRODUCTION 14
2. BACKGROUND 16
2.1. Type 2 diabetes mellitus (T2DM) 16
2.2. Prediabetes 18
2.3. Oxidative stress markers 21
2.3.1. Malondialdehyde (MDA) 21
2.3.2. Oxidized low-density lipoprotein (ox-LDL) 23
2.3.3. 8-epi-Prostaglandin F2α (8-epi-PGF2α)[이미지참조] 24
2.4. Single nucleotide polymorphisms (SNPs) 26
2.5. T2DM-related SNPs 27
2.6. Genetic risk score (GRS) 28
2.7. Korean chip (K-CHIP) 29
3. MATERIALS AND METHODS 30
3.1. Study population 30
3.2. SNP selection and SNP chip analysis 31
3.3. GRS and OSS construction 33
3.4. Laboratory assessments 35
3.5. Statistical analysis 38
4. RESULTS 39
4.1. Clinical characteristics 39
4.2. Association of the SNP loci with prediabetes and T2DM and construction of the GRS 43
4.3. Associations between the OSS and incidence of prediabetes and T2DM 45
4.4. Optimal cutoff thresholds of risk factors for the incidence of prediabetes and T2DM 47
5. DISCUSSIONS 51
6. CONCLUSION 60
7. REFERENCES 61
ABSTRACT 76
국문요약 79
Table 1. Current diagnostic criteria for prediabetes and diabetes 20
Table 2. Clinical and biochemical characteristics of the normal vs. prediabetes and T2DM groups 41
Table 3. Association of 9 SNP loci with the normal vs. prediabetes and T2DM groups 44
Table 4. Associations of oxidative stress biomarkers with prediabetes and T2DM in a Korean population 46
Table 5. Odds ratios for the risk factors on the incidence of prediabetes and T2DM in a Korean population 49
Figure 1. MDA formation through lipid peroxidation. 22
Figure 2. Pathway for enzymatic synthesis of prostaglandin F2α.[이미지참조] 25
Figure 3. ROC curves for the BMI, OSS, and GRS 50