A slightly acidic and hypoxic environment is found in common solid cancers. Nanoparticles containing ferrocene and azobenzene groups can control drug release by the concentration of reactive oxygen species (ROS) and oxygen. In this study, ferrocenylmethyl methacrylate (FMMA)- Methacrylic acid (MA)- [Methacrylic acid - 4,4'-Azodianiline - Azobenzene-4,4′-dicarboxylic acid - Doxorubicin (MA-DOX)] random copolymer, i.e., ferrocene and azobenzene polymers containing groups were synthesized through radical polymerization. And, ferrocene-doxorubicin-containing nanooparticles (FDNPs), which are highly reactive to tumor microenvironments, were prepared using the synthesized polymer. The spherical FDNPs synthesized had a diameter of about 120-150 nm and an average surface charge of -33.6 mV. FDNPs reacted sensitively to H₂O₂ and Na₂S₂O₄ used as ROS and hypoxia models respectively, and it was confirmed that they were completely degraded after 24 hours. In addition, the drug release controlled by the tumor microenvironment suggests that the prepared FDNPs have great potential as drug carriers to effectively treat various cancers.