표제지
목차
ABSTRACT 7
I. 서론 9
II. 방법 10
1. 동물 및 군 분리 10
2. 시료의 구입 및 관리 12
3. Morris water maze test 13
(1) Training day 14
(2) Hidden platform test 14
(3) Probe test 14
4. Collection of brain tissue 15
5. Western blotting analysis 16
6. Biochemical assay 17
7. Statistical analysis 18
III. 결과 19
1. Morris water maze test 19
(1) Latency time to target 19
(2) Target crossing time 21
2. Western blotting analysis 23
(1) BDNF neural expression 23
(2) p-CREB neural expression 25
(3) iNOS neural expression 27
(4) mAch R1 neural expression 29
3. Biochemical assay 31
(1) Ach concentration 31
(2) AchE activity 33
IV. 고찰 35
V. 결론 40
참고문헌 41