Title Page
Contents
Abstract 8
I. INTRODUCTION 10
II. MATERIALS AND METHODS 12
1. Patients 12
2. Imaging Acquisition 14
3. Image Postprocessing and Analysis 20
4. Molecular/Genetic Analysis 22
5. Statistical Analysis 23
III. RESULTS 24
1. Clinical Characteristics 24
2. Histogram Analysis 27
3. Subgroup Analysis in Groups MM and MU 33
4. Conventional Imaging Features and Volume Measurements Among the Three Groups 37
IV. DISCUSSION 40
V. CONCLUSION 44
REFERENCES 45
ABSTRACT IN KOREAN 51
Table 1. Clinical characteristics of the patients 25
Table 2. Histogram parameters among the three groups 28
Table 3. Diagnostic performance of the nrCBV values for discriminating unchanged MGMT methylation status (Group MM) from... 36
Supplementary Table 1. MR parameters 16
Supplementary Table 2. The ratio of histogram values among three groups 32
Supplementary Table 3. Comparison of Histogram imaging parameters between two groups of initially methylated MGMT, Group... 34
Supplementary Table 4. Conventional imaging features and tumor volumes of initial and recurrent tumors among three groups 38
Figure 1. Study design 13
Figure 2. The ROIs were determined with semiautomatic segmentation with thresholds... 19
Figure 3. The ROIs were determined with semiautomatic segmentation with thresholds... 30
Figure 4. Comparison of nrCBV histogram parameters across each group of NER in... 31