Title Page
Contents
ABSTRACT IN KOREAN 7
I. INTRODUCTION 9
II. MATERIALS AND METHODS 13
1. Participants 13
2. Clinical assessments 14
3. Genotyping 14
4. MRI data acquisition 15
5. DTI analysis 16
6. Statistical analysis 17
III. RESULTS 18
1. Genotyping, sociodemographic, and clinical characteristics of the study participants 18
2. Baseline comparison of hippocampal WM connectivity between the IM and EM groups 21
3. Relationships among CYP2D6 activity, hippocampal WM connectivity, and treatment response 24
IV. DISCUSSION 28
V. CONCLUSION 32
REFERENCES 33
ABSTRACT IN ENGLISH 42
Table 1. Sociodemographic and clinical characteristics of all subjects at baseline scan 20
Table 2. Sociodemographic and clinical characteristics of the 4-week follow-up group 25
Fig. 1. White matter regions of interest 22
Fig. 2. Comparison of hippocampal white matter connectivity between IM and EM... 23
Fig. 3. Associations between CYP2D6-associated hippocampal white matter... 27