Title Page
Contents
Abstract 7
Chapter 1. Introduction 8
Chapter 2. Materials and Methods 10
2.1. CT scan and bolus fabrication 10
2.1.1. CT image acquisition 10
2.1.2. Effective density measurements 10
2.2. Radiation treatment planning 13
2.2.1. Registration of CT image 13
2.2.2. Segmentation 13
2.2.3. Analysis of DVH and dose distributions 13
2.3. Humanoid phantom measurements 15
2.3.1. Characteristics of OSLD 15
2.3.2. OSLD measurement 15
Chapter 3. Results 20
3.1. Verification of effective density 20
3.2. DVH analysis 22
3.3. OSLD measurements 30
Chapter 4. Discussion and Conclusion 37
4.1. Discussion 37
4.2. Conclusion 39
References 40
국문초록 44
Table 1. Characteristics of OSLD system 17
Table 2. Effective density at the assigned points 21
Table 3. Dose distribution at 95% of the total structural volume 28
Table 4. Min/Max dose distribution in the specified contour of DVH 29
Table 5. OSLD measurements vs. treatment plan (with bolus) 31
Table 6. OSLD measurements vs. treatment plan (without bolus) 32
Fig. 1. CT image acquisition A: Matching the centerline... 11
Fig. 2. Fabricating custom-made helmet bolus procedure A: Overlaid the thermoplastic mask... 12
Fig. 3. Contouring of the scalp treatment Based on the bolus, the contour behave as two different contours performing to... 14
Fig. 4. OSLD calibration procedure Once the OSLD chips were registered and then proceeded with calibration for... 18
Fig. 5. Assigned points of OSLD A: Vertex (VX)... 19
Fig. 6. Dose-volume histogram of CTV with/without helmet bolus In the scalp treatment using the VMAT technique, the delivered dose per... 23
Fig. 7. Dose-volume histogram of the brain with/without helmet bolus In the scalp treatment using the VMAT technique, the delivered dose per... 24
Fig. 8. Dose-volume histogram of the skull with/without helmet bolus In the scalp treatment using the VMAT technique, the delivered dose per... 25
Fig. 9. Dose-volume histogram of the eye with/without helmet bolus In the scalp treatment using the VMAT technique, the delivered dose per... 26
Fig. 10. Dose-volume histogram of the lens with/without helmet bolus In the scalp treatment using the VMAT technique, the delivered dose per... 27
Fig. 11. Dose-volume histogram at VX with/without helmet bolus 33
Fig. 12. Dose-volume histogram at PO with/without helmet bolus 34
Fig. 13. Dose-volume histogram at RT with/without helmet bolus 35
Fig. 14. Dose-volume histogram at LT with/without helmet bolus 36