The fishing activity of Venezuela is mainly focused on the production of two marine fisheries such as tuna and sardine, amount to approximately 54% of total national catches, being the first item of artisanal origin and the second object of industrial offshore fishing, both generate an important level of employment and industrial movement within the sector. Venezuela became a full-member of the Inter-American Tropical Tuna Commission (IATTC) in 1992. This, helped the country establish a solid fishing fleet operating in the Eastern Pacific Ocean (EPO). The present study performs an assessment of Venezuela's tuna fishery in the EPO. By the bioeconomic model, the study analyses fishing data (catch and effort) for last 26 years (1993-2018), employing one of the exponential growth model in surplus production model: Clarke, Yoshimoto and Pooley (CPY). The results of the model show that the fishing effort (associated to boat size) and the catch should be reduced by 34 % and 24 %, respectively, in order to harvest fisheries resources of the EPO and maintain economic profitability. Determining accuracy of the model Theil's U-statistics is estimated to be 0.64, which implies that estimated catches of the model and actual catches represent quite similar. Therefore, it is necessary to implement effective management measures and policies, to evaluate how to reduce the fishing effort and catch.