표제지
목차
국문 초록 9
I. 서론 11
1. 연구 배경 11
1) 눈물막 11
2) 건성안 14
3) 건성안의 판단 요소 18
2. 연구 목적 20
II. 연구대상 및 방법 21
1. 연구대상 21
2. 연구 방법 및 도구 22
1) 객관적(타각적) 건성안 검사 23
2) 설문 30
3. 건성안 정량화를 위한 점수산출 36
III. 결과 및 고찰 37
1. 대상자의 특성 37
2. 객관적 건성안 판별 요소 38
1) 비침습적눈물막파괴시간(None Invasive tear film Break Up Time) 38
2) 지질층의 두께(Lipid layer thickness) 44
3) 마이봄샘 손실도(Meibomian glands - Loss area) 47
4) 눈물프리즘높이(Tear meniscus hight) 50
3. 주관적인 건성안 판별 요소 52
1) SPEED(Standard Patient Evaluation of Eye Dryness) 52
2) OSDI(Ocular Surface Disease Index) 54
3. 건성안 판별 요소별 비교 56
4. 건성안 정량화를 위한 점수 산출 59
IV. 결론 63
참고문헌 65
Abstract 71
설문지 73
Table 1. General characteristics of the subject 21
Table 2. Sort of Objective element and Subjective element 22
Table 3. Classification of dry eye 36
Table 4. Chracteristics of subjects 37
Table 5. Eye counts and percentages per second 40
Table 6. Dry eye by NIBUT 41
Table 7. Dry eye in NIBUT ratio depending on whether contact... 42
Table 8. Lipid layer thickness according to gender 45
Table 9. Lipid layer thickness according to gender by type 46
Table 10. Meibomian glands Rate by grade according to gender 48
Table 11. Meniscus height by gender 51
Table 12. SPEED dry Eye Ratio by Gender 53
Table 13. OSDI by Group 55
Table 14. OSDI dry Eye Ratio by Gender 55
Table 15. Descriptive statistics of factors 56
Table 16. Comparison of means and normal criteria 57
Table 17. Percentage of dry eyes in the dry eye discrimination factors... 58
Table 18. Dry eye constants and coefficients determined quantitatively 60
Table 19. Quantitatively Assessed Dryness Score Results 62
Table 20. Comparison of the similarity of the ratio between OSDI and... 62
Fig. 1. Structure of tear layers. 12
Fig. 2. How Color Fringe Appears. 18
Fig. 3. OSA(Ocular Surface Analysis, SMB, Italy). 23
Fig. 4. Result of ocular surface analysis by OSA. 24
Fig. 5. Measure NIBUT(None invasive tear film break up time) 25
Fig. 6. Method of determine the thickness of the lipid layer. 27
Fig. 7. Meibomian Glands Loss area. 28
Fig. 8. Tear meniscus height. 29
Fig. 9. Percentage of dry eye and non dry eye in NIBUT 39
Fig. 10. NIBUT distribution map. 39
Fig. 11. NIBUT Change according to wearing period of contact lens 41
Fig. 12. Percentage of dry eye and non dry eye in Lipid layer... 44
Fig. 13. Percentage of meibomian loss by grade. 47
Fig. 14. Meibomian glands Rate by Contact Lens. 49
Fig. 15. Tear meniscus hight distribution map. 50
Fig. 16. SPEED distribution map by score. 52
Fig. 17. OSDI distribution map by score. 54
Fig. 18. Normalized P-P graph of standardized residuals for... 60