표제지
목차
제1장 연구개요 9
1. 레몬 머틀(Lemon Myrtle) 9
2. 항염증 연구 현황 12
3. 주요 질환관련 연구 현황 19
제2장 연구 내용 28
제1절 LPS로 유도된 RAW 264.7 세포에 대한 레몬 머틀 잎 추출물의 항염증 효과 28
1. 서론 28
2. 재료 및 방법 29
3. 결과 및 고찰 34
4. 요약 46
제2절 레몬 머틀 잎 추출물의 Hep G2 세포에서의 간 보호 효과 및 알코올 대사효소 활성 47
1. 서론 47
2. 재료 및 방법 48
3. 결과 및 고찰 51
4. 요약 60
제3장 결론 61
제4장 참고문헌 63
초록 77
ABSTRACT 79
Table 1. Overview of depigmentation agents and their mode of action. 24
Table 2. Total polyphenol contents of Lemon Myrtle (Backhousia citriodora) leaf... 35
Table 3. Inhibitory effects of lemon myrtle (Backhousia citriodora) leaf extracts... 53
Table 4. Tyrosinase inhibitory activities of lemon myrtle (Backhousia citriodora)... 54
Fig. 1. Flower and Leaf of Lemon Myrtle. 10
Fig. 2. Schematic overview of how metabolic syndrome develops from... 13
Fig. 3. Overview of how PPARs are involved in fat storage, lipogenesis, and... 15
Fig. 4. Signalling pathway of inflammatory gene expression in obese adipose... 17
Fig. 5. Structures of acarbose, miglitol, voglibose, and DNJ. 21
Fig. 6. Chemical structure of the different depigmentation agents and their... 23
Fig. 7. Schematic diagram of major pathways of alcoholic fatty liver (ALD)... 27
Fig. 8. DPPH free radical scavenging activity of lemon myrtle (Backhousia citriodora)... 37
Fig. 9. Superoxide dismutase (SOD) activity of lemon myrtle (Backhousia citriodora) leaf... 39
Fig. 10. Nitrite scavenging effects of Lemon Myrtle (Backhousia citriodora) leaf extracts... 41
Fig. 11. Effects of Lemon Myrtle (BackllOusia citriodora) leaf extracts on cell viability (A)... 43
Fig. 12. Inhibitory effects of Lemon Myrtle (Backhousia citriodora) leaf extracts on the... 45
Fig. 13. Effects of lemon myrtle (Backhousia citriodora) leaf extracts on the alcohol... 56
Fig. 14. Effects of lemon myrtle (Backhousia citriodora) leaf extracts on the acetaldehyde... 57
Fig. 15. Hepatoprotective effects of lemon myrtle (Backhousia citriodora)... 59