Title Page
Contents
Introduction 7
Methods 9
Patient Eligibility 9
MDR1 genotyping and haplotype analysis 9
Study protocol 9
Statistical analysis 10
Results 12
Baseline Characteristics 12
MDR1 genotyping 12
Discussion 15
References 20
요약 35
Table 1. Baseline Characteristics of the patients of HBe Ag positive 24
Table 2. Hardy-Weinberg Equilibrium & minor allele frequency of MDR1 25
Table 3. Allele frequency of polymorphism of MDR1 in the patient with or without seroconversion of HBe Ag 26
Table 4. Characteristics according to SNPs of MDR1 genotypes 27
Table 5. The Association of MDR1 C3435T in the virologic response at 12, 24, and 48 weeks 28
Table 6. Predictive factors for Virologic breakthrough in Chronic hepatitis B with HBe Ag positive 29
Table 7. Median duration for breakthrough(BT) free duration according to genotype and virologic response at 24 weeks 30
Figure 1. The study diagram 31
Figure 2. The linkage disequilibrium measure of MDR1 gene 32
Figure 3. Breakthrough(BT) free duration according to the C3435T SNP in the MDR1 gene (A) and the presence of HBe Ag loss (B). 33