표제지
국문초록
목차
I. 서론 14
II. 재료 및 방법 16
1. 재료 16
1) 약재 16
2) Cell lines 16
3) 시약 및 기기 16
(1) 시약 16
(2) 기기 17
2. 방법 17
1) 시료의 제조 17
(1) 何首烏 물추출물 제조 17
2) 세포 배양 18
3) 세포생존율 검사 18
4) NO 생성 측정 19
5) Cytokine 생성 측정 19
6) 세포내 칼슘 생성 측정 20
3. 통계처리 21
III. 결과 22
1. 세포생존율 22
2. LPS로 유발된 NO 생성증가에 대한 영향 24
3. LPS로 유발된 세포내 칼슘생성증가에 대한 영향 26
4. LPS로 유발된 cytokine 생성증가에 대한 영향 28
1) IL-lα 생성에 대한 영향 28
2) IL-3 생성에 대한 영향 30
3) IP-10 생성에 대한 영향 32
4) KC 생성에 대한 영향 34
5) VEGF 생성에 대한 영향 36
6) IL-1β 생성에 대한 영향 38
7) IL-2 생성에 대한 영향 40
8) IL-4 생성에 대한 영향 42
9) IL-6 생성에 대한 영향 44
10) IL-5 생성에 대한 영향 46
11) IL-10 생성에 대한 영향 48
12) IL-13 생성에 대한 영향 50
13) IFN-γ 생성에 대한 영향 52
14) IL-17 생성에 대한 영향 54
IV. 고찰 56
V. 결론 70
참고문헌 72
ABSTRACT 81
Table 1. Effect of PM on Cell Viability of RAW 264.7 cells 22
Table 2. Effect of PM on NO Production of LPS-induced RAW 264.7 cells 24
Table 3. Effect of PM on Calcium Production of LPS-induced RAW 264.7 cells 26
Table 4. Effect of PM on IL-lα Production of LPS-induced RAW 264.7 cells 28
Table 5. Effect of PM on IL-3 Production of LPS-induced RAW 264.7 cells 30
Table 6. Effect of PM on IP-10 Production of LPS-induced RAW 264.7 cells 32
Table 7. Effect of PM on KC Production of LPS-induced RAW 264.7 cells 34
Table 8. Effect of PM on VEGF Production of LPS-induced RAW 264.7 cells 36
Table 9. Effect of PM on IL-1β Production of LPS-induced RAW 264.7 cells 38
Table 10. Effect of PM on IL-2 Production of LPS-induced RAW 264.7 cells 40
Table 11. Effect of PM on IL-4 Production of LPS-induced RAW 264.7 cells 42
Table 12. Effect of PM on IL-6 Production of LPS-induced RAW 264.7 cells 44
Table 13. Effect of PM on IL-5 Production of LPS-induced RAW 264.7 cells 46
Table 14. Effect of PM on IL-10 Production of LPS-induced RAW 264.7 cells 48
Table 15. Effect of PM on IL-13 Production of LPS-induced RAW 264.7 cells 50
Table 16. Effect of PM on IFN-γ Production of LPS-induced RAW 264.7 cells 52
Table 17. Effect of PM on IL-17 Production of LPS-induced RAW 264.7 cells 54
Fig. 1. Effect of PM on Cell Viability of RAW 264.7 cells 23
Fig. 2. Effect of PM on NO Production of LPS-induced RAW 264.7 cells 25
Fig. 3. Effect of PM on Calcium Production of LPS-induced RAW 264.7 cells 27
Fig. 4. Effect of PM on IL-lα Production of LPS-induced RAW 264.7 cells 29
Fig. 5. Effect of PM on IL-3 Production of LPS-induced RAW 264.7 cells 31
Fig. 6. Effect of PM on IP-10 Production of LPS-induced RAW 264.7 cells 33
Fig. 7. Effect of PM on KC Production of LPS-induced RAW 264.7 cells 35
Fig. 8. Effect of PM on VEGF Production of LPS-induced RAW 264.7 cells 37
Fig. 9. Effect of PM on IL-1β Production of LPS-induced RAW 264.7 cells 39
Fig. 10. Effect of PM on IL-2 Production of LPS-induced RAW 264.7 cells 41
Fig. 11. Effect of PM on IL-4 Production of LPS-induced RAW 264.7 cells 43
Fig. 12. Effect of PM on IL-6 Production of LPS-induced RAW 264.7 cells 45
Fig. 13. Effect of PM on IL-5 Production of LPS-induced RAW 264.7 cells 47
Fig. 14. Effect of PM on IL-10 Production of LPS-induced RAW 264.7 cells 49
Fig. 15. Effect of PM on IL-13 Production of LPS-induced RAW 264.7 cells 51
Fig. 16. Effect of PM on IFN-γ Production of LPS-induced RAW 264.7 cells 53
Fig. 17. Effect of PM on IL-17 Production of LPS-induced RAW 264.7 cells 55