Title Page
국문초록
Contents
I. Introduction 9
II. Materials and Methods 11
1. Materials 11
2. Cell culture 11
3. Cell viability assay 11
4. Apoptosis evaluation 12
5. Western blot analysis 13
6. Statistical Analysis 13
III. Results 14
1. Cell growth by SVT 14
2. Apoptotic cell death by SVT 16
3. Expression of apoptotic regulatory proteins by SVT 18
4. Effect of SVT on activation of NF-κB signal molecules and STAT3 20
5. Synergic effect of salicylic acid and stattic on SVT-induced cell growth inhibition 22
IV. Discussion 24
References 27
ABSTRACT 33
Fig. 1. Effect of SVT on cell viability in ovarian cancer cells. 15
Fig. 2. Effect of SVT on apoptotic cell death. 17
Fig. 3. Effect of SVT on the expression of apoptosis regulatory proteins. 19
Fig. 4. Effect of SVT on the activation of NF-κB/STAT3 in ovarian cancer cells. 21
Fig. 5. Effect of salicylic acid and stattic, NF-κB and STAT3 inhibitors on the SVT-induced cancer cell growth inhibition in PA-1 ovarian cancer cells. 23