표제지
목차
PART 1. 羌活에 대한 문헌적 고찰 9
I. 緖論 10
II. 本論 12
1. 羌活의 異名에 관한 조사 12
2. 羌活의 鑑別 12
3. 羌活의 性味에 관한 조사 14
4. 羌活의 歸經에 관한 조사 14
5. 羌活의 效能 主治에 관한 조사 15
6. 羌活의 성분에 관한 조사 16
7. 羌活의 약리작용에 관한 조사 17
III. 結論 20
參考文獻 22
ABSTRACT 24
PART 2. 마우스에서 羌活 에탄올추출물의 記憶力 減退에 대한 改善 效果 26
I. 緖論 27
1. 現代醫學에서의 痴保 28
2. 韓醫學에서의 痴保 30
3. 本草學에서의 羌活 31
4. 韓藥 藥理學에서의 羌活 32
II. 材料 및 方法 34
1. 實驗材料 34
2. 실험方法 36
3. 통계처리 42
III. 實驗結果 43
1. 수동회피반응 시험 (Passive avoidance task) 43
2. Y-미로 실험 (Y-maze task) 46
3. 모리스 수중 미로 시험 (Morris water maze task) 50
4. Acetylcholinesterase(AchE) 활성 56
IV. 考察 58
V. 結論 63
參考文獻 65
국문초록 68
ABSTRACT 70
표 1. 羌活의 異名에 관한 조사 12
표 2. 羌活의 鑑別 13
표 3. 羌活의 性味에 관한 조사 14
표 4. 羌活의 歸經에 관한 조사 15
표 5. 羌活의 效能 主治에 관한 조사 16
표 6. 羌活의 사용 시 주의사항 18
표 7. 羌活이 사용된 處方 19
Table 1. Effect of a single administration of 70% EtOH extract of Ostericum Koreanum (EEOK) scopolamine-induced memory deficits in the passive avoidance test in mice 44
Table 2. Effect of a Single Administration of 70% EtOH extract of Ostericum Koreanum (EEOK) Scopolamine-induced Memory Deficits in the Y-maze Test in Mice. 47
Table 3. Effects of 70% EtOH extract of Ostericum Koreanum (EEOK) in Morris water Maze during 4 day 51
Table 4. Effects of 70% EtOH extract of Ostericum Koreanum(EEOK) on 6th day Retention in Morris water Maze 54
Figure 1. Gemini avoidance system 37
Figure 2. Y-maze task 39
Figure 3. Morris water maze 40
Figure 4. Effect of the 70% EtOH extract of Ostericum Koreanum (EEOK) on scopolamine-induced memory impairment mice in the passive avoidance task. At 60min before test, tacrine (10 mg/kg, p.o.), control (same volume of saline) and... 45
Figure 5. Effect of the 70% EtOH extract of Ostericum Koreanum (EEOK) on scopolamine-induced memory impairment mice in the Y-maze test. At 60 min before test, tacrine (10 mg/kg, p.o.), control (same volume of saline) and EEOK(12.5,... 49
Figure 6. Effect of the 70% EtOH extract of Ostericum Koreanum (EEOK) on performance in the training trial sessions of the Morris water maze test in scopolamine-induced memory deficits mice. At 60 min before training trial session, EEOK (50... 52
Figure 7. Effect of the 70% EtOH extract of Ostericum Koreanum (EEOK) on swimming time during the probe trial session of the Morris water maze task in scopolamine-induced memory deficits mice. At 60 min before training trial sessions,... 55
Figure 8. Acetylcholine esterase activity was inhibited by 70 % EtOH extract of Ostericum Koreanum (EEOK) in a dose-dependant manner. The concentration required for 50 % enzyme inhibition (IC50) of EEOK was 185.4 ug/ml. Inhibition...(이미지참조) 57