Edible and medicinal mushrooms have been immensely popular in Asia for millennia. There are primarily three ways to extract the medicinal compounds from these mushrooms. Each method pulls out different compounds, all of which have been proven by scientific research to be therapeutically important. The first is hot water extraction for polysaccharides, etc., and the second is alcohol/ethanol extraction for triterpenoids, etc., and the third is fermenting for arabinoxylanes, etc. In this study, hot water extraction methods were used to make soap, cosmetic face pack and drinking pouch products for the application to the skin with atopic dermatitis and acne symptoms by Propionibacterium acne. The complex mushroom extracts are made of the following seven edible and medicinal mushrooms; Tremella fuciformis, Cordyceps militaris, Ganoderma lucidum, Lentinus edodes, Agaricus blazei Muril, Phellinus linteus, and Inonotus obliquus. Preliminary clinical trials were progressed and the results were recorded for 4 weeks. Total number of patients with atopic dermatitis were 15 and 5 patients with severe acne sympotoms. Daily treatment with these mushroom soap, face pack and pouch drinks was performed and questionnaire sheets were written to check the improvement. According to photos taken before and after the treatment and questionnaire results, considerable improvements in skin conditions are observed in the patients with atopic dermatitis and acne. For atopic patients, erythema and edema have been improved but the degree of effect was dependent on the individual's constitution. Concerning acne, the effect of coating of the extracts was prominent for first week and the degree decreased with time till 4 weeks. The complex mushrooms extracts were efficient in soothing rash and maturation. Side effects such as a scar were not detected during the application and treatment. For patients with both symptoms, oil and moisture balance were good also.