표제지
목차
I. 서론 9
II. 본론 11
1. 겨우살이란 11
1) 일반현황 11
2) 분포 및 특징 11
3) 계절별 생육 12
2. 겨우살이의 연구사 15
1) 학위논문 16
2) 국내 학술지 21
3. 겨우살이의 이화학적 특성 27
4. 겨우살이의 기능(효능)성 29
1) 항암 29
2) 항종양 29
3) 면역증강 30
4) 항당뇨 30
5) 항고혈압 31
6) 항산화 31
5. 건강기능식품공전에 나타난 겨우살이 32
1) 정의 32
2) 원료 등의 구비요건 32
3) 제조 · 가공기준 32
4) 식품유형 33
5) 규격 33
6) 시험방법 33
6. 겨우살이등 건강기능식품 업소 현황 34
1) 건강기능식품 제조(판매)업소 현황(2005-2007)(26) 35
2) 건강기능식품 시·도별 제조업소수(2007)(26) 36
3) 건강기능식품 수입업소 수(2007)(26) 37
4) 건강기능식품 판매업소 수(2007)(26) 38
5) 건강기능식품 품목(2007)(26) 39
6) 건강기능식품 GMP지정업소 수 - 시도별(2005-2007)(26) 40
7) 건강기능식품 매출액 - 품목유형별 : 2007(26) 41
8) 건강기능식품 제조업소 행정처분 등 : 2007(26) 42
9) 건강기능식품 기능성표시·광고 심의현황 - 매체별 : 2006-2007(26) 44
10) 건강기능식품 수입현황 - 품목유형별, 기관별 : 2007(26) 45
11) 수입 건강기능식품 검사현황 - 기관별 : 2007(26) 46
12) 상위 10개 국가 수입 건강기능식품 검사현황 : 2007(26) 48
7. 겨우살이의 지표성분 및 Lectine의 특성 49
1) Lectine이란 49
2) Lectine의 구성성분(31) 51
3) 겨우살이 Lectine의 특성 52
4)겨우살이 Lectine과 다른식물 Lectine의 비교 60
8. 겨우살이의 이용실태 및 상품화 현황 67
1) 액상제품 67
2) 차(미슬토) 67
3) 정 및 丸 68
4) 겨우살이 원료 69
9. 겨우살이의 (계절별) 성분 분석 비교 70
1) 겨우살이의 일반성분 비교분석 70
2) 잎, 줄기, 열매의 암세포 성장 억제효과 73
3) 건조된 겨우살이의 암세포 성장억제 효과 74
4) 여름산, 겨울산 겨우살이의 암세포 성장억제 효과 75
III. 결론 76
IV. 요약 78
V. 영문초록 80
VI. 참고문헌 82
Table 1. Classification of growth stages by the time of the year 13
Table 2. 겨우살이 유기추출물의 황산화 활성 32
Table 3. Number of health functional foods establishments by businesstype (2005-2007) 35
Table 4. Number of health functional foods manufactures by province(city) : 2007 36
Table 5. Number of health functional foods importers by province(city) office : 2007 37
Table 6. Health functional foods sales establishments by province(city) : 2007 38
Table 7. Health functional foods establishments : 2007 39
Table 8. Number of Status of good manufacturing practice establishments of health functional foods province(city) : 2005-2007 40
Table 9. Sales of health functional foods by item type : 2007 41
Table 10. Administrative measures on health functional food 42
Table 11. Sales of health functional foods by item type : 2007 44
Table 12. Status of imported health functional foods by item type and institution : 2007 45
Table 13. Inspection of imported health functional foods by institution.: 2007 47
Table 14. Status of imported health functional foods - top ten countries : 2007 48
Table 15. Anti -cancer effect of various lectins in vitro and in vivo 50
Table 16. Stages in the Punfication of Lectin from Pseudixus japonicus 51
Table 17. Prophylactic effect of KM-110 on lung metastasis produced by i.v. inoculation of B16-Bl6 melanoma or Colon 26-M3.1 carcinoma cells. 54
Table 18. Prophylactic effect of KM-110 on liver and spleen metastas is produced by i.v. inoculation of L5178Y-ML25 lymphoma cells. 54
Table 19. Therapeutic effect of KM-110 on the metastasis mediated by colon26-M3.1.cells 55
Table 20. Therapeutic effect of KML-1 on the liver, spleen or lung metastasis in mice 56
Table 21. Proximate compositions(% W/W) of mistletoe 61
Table 22. Comparison of cytotoxicity to various tumor cells between KML-1 and EML- 1 62
Table 23. Blood group specificity of som ecrude lectine 64
Table 24. Blood group specificity of mushrooms 65
Table 25. Blood group specificity of Marine Animals 66
Table 26. 겨우살이 액상제품의 상품사진 및 특성 67
Table 27. 차 제품 67
Table 28. 겨우살이 정 및 환 제품 현황 68
Table 29. 겨우살이 제품 및 원료 69
Table 30. Proximate composition of Mistletoe, Viscum album L. 72
Fig 1. Birth and breeding of viscum for each season 14
Fig 2. Ingredient of Viscum album 27
Fig 3. 한국산 겨우살이 dichloromethane 분획으로부터 황산화 활성 측정 31
Fig 4. 건강기능식품 관련업소 현황 34
Fig 5. 건강기능식품 매출액(2007년) 34
Fig 6. Diagram of anticancer action by anticancer immunocyte 52
Fig 7. Effect of serum treatment with KM-100 on B16-BL6 melanoma cells 57
Fig 8. Effect of KM-110 and KML-1 on the production of antibody to Keyhole Limpet Hemocyanin (KLH) 58
Fig 9. Antigen specific proliferation of splenocytes from mice immunized with KLH 59
Fig 10. Feature of European Viscum album and molecular structure of lectin of Viscum album 60
Fig 11. Dose-dependent inhibition of growth of HL-60 cells by methanol extract of Korean and European mistletoe 63
Fig 12. Proximate composition of Mistletoe, Viscum album L. 72
Fig 13. Dose-dependent inhibition of Molt-4 and HL-60 by water extract of korean mistletoe and lectin concentration 73
Fig 14. Dose-dependent inhibition of Growth of HL-60 by water extract of dreid Korean and European mistletoe 74
Fig 15. Dose-dependent inhibition of Growth of HL-60 cells by water extract of summer and winter of Korean mistletoe. 75