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1. 서론 15
1.1. 연구의 필요성 15
1.2. 연구의 목적 17
2. 이론적 배경 18
2.1. 암 18
2.1.1. 암 발생률 18
2.1.2. 암 사망률 20
2.1.3. 암 생존율 20
2.2. 암 치료 21
2.2.1. 수술요법 21
2.2.2. 항암요법 21
2.2.3. 방사선치료 22
2.2.4. 전리방사선과 물질과의 상호작용 22
2.2.5. 암 치료용 선형가속기 26
2.3. 온열치료 36
2.3.1. 온열치료 효과 36
2.3.2. 온열치료기 37
2.4. 한천 팬텀 42
2.4.1. 한천의 성분 42
2.4.2. 한천의 구조 43
2.5. 겔 보루스 43
2.6. 온도 측정 센스 45
2.6.1. Tempsens 온도측정기 45
2.6.2. GaAs 유리섬유 온도센스 47
2.7. 고주파전류 49
2.8. 유전율 50
2.9. 전자파 흡수율 51
3. 연구 방법 58
3.1. 한천 팬텀 틀 제작 58
3.2. 한천 팬텀 제작 59
3.2.1. 한천 팬텀 비율 59
3.2.2. 한천 팬텀 제작 61
3.3. 온도 측정 62
3.3.1. 한천 팬텀 비율에 따른 온도 측정 62
3.3.2. 한천 팬텀 제작 후 시간에 따른 온도 측정 63
3.3.3. 한천 팬텀 출력 전력별 온도 측정 64
3.3.4. 한천 팬텀 평탄도 측정 64
3.3.5. 겔 보루스 팬텀 온도 측정 66
4. 연구 결과 67
4.1. 실험에 대한 결과 67
4.1.1. 한천 팬텀 비율에 따른 온도 측정결과 67
4.1.2. 한천 팬텀 제작 후 시간에 따른 온도 측정결과 80
4.1.3. 한천 팬텀 출력 전력별 온도 측정결과 95
4.1.4. 한천 팬텀의 평탄도 측정결과 140
4.1.5. 겔 보루스 팬텀 온도 측정결과 152
4.1.6. 한천 팬텀과 겔 보루스 팬텀 온도 측정 비교 분석 158
5. 고찰 및 결론 170
요약 173
참고문헌 174
Abstract 179
Table 1. Trends in cancer incidence rates in both sexes between 2007 ~ 2013... 19
Table 2. Trends in cancer incidence rates in both sexes Korea, 2013 19
Table 3. Trends in the 5-year relative survival rates between 1993 ~ 2013 in... 21
Table 4. Task group 142 report: daily QA of medical accelerators 27
Table 5. Task group 142 report: monthly QA of medical accelerators 28
Table 6. Task group 142 report: annual QA of medical accelerators 30
Table 7. Hyperthermia TCS System along with the computer 39
Table 8. Display and the operating controls 40
Table 9. Specifications of Tempsens 46
Table 10. Specifications of fiber optic temperature sensor 48
Table 11. Dielectric properties of biological tissue equivalent solution 52
Table 12. The relative permittivity of biological tissues at 37 ℃ for various... 53
Table 13. The composition and properties of agar-based phantoms... 54
Table 14. Dielectric parameters of agar phantom. The values of relative... 55
Table 15. The ingredients and various characteristics of gelatin-based... 56
Table 16. Powder agar 4% mixing ratio 69
Table 17. Powder agar 5% mixing ratio 72
Table 18. Powder agar 6% mixing ratio 75
Table 19. Powder agar 7% mixing ratio 78
Table 20. Measurement of temperature after 3hours of agar phantom... 81
Table 21. Measurement of temperature after 22hours of agar phantom... 84
Table 22. Measurement of temperature after 49hours of agar phantom... 87
Table 23. Measurement of temperature after 72hours of agar phantom... 90
Table 24. Measurement of temperature after 96hours of agar phantom... 93
Table 25. The result of measuring the core body temperature from each... 96
Table 26. The result of measuring the core body temperature from each... 99
Table 27. The result of measuring the core body temperature from each... 102
Table 28. The result of measuring the core body temperature from each... 105
Table 29. The result of measuring the core body temperature from each... 108
Table 30. The result of measuring the core body temperature from each... 111
Table 31. The result of measuring the core body temperature from each... 114
Table 32. The result of measuring the core body temperature from each... 117
Table 33. The result of measuring the core body temperature from each... 120
Table 34. The result of measuring the core body temperature from each... 123
Table 35. The result of measuring the core body temperature from each... 126
Table 36. The result of measuring the core body temperature from each... 129
Table 37. The result of measuring the core body temperature from each... 132
Table 38. The result of measuring the core body temperature from each... 135
Table 39. The result of measuring the core body temperature from each... 138
Table 40. Temperature profile of transverse section along with 0㎝ depth 141
Table 41. Temperature profile of transverse section along with 5㎝ depth 144
Table 42. Temperature profile of transverse section along with 10㎝ depth 147
Table 43. Temperature profile of transverse section along with 15㎝ depth 150
Table 44. Depth of measurement temperature on gel bolus phantom for... 153
Table 45. Depth of measurement temperature on gel bolus phantom for... 156
Table 46. 5㎝ depth for 60minutes to heat 100 W of measurement agar... 159
Table 47. 5㎝ depth for 60minutes to heat 150 W of measurement agar... 161
Table 48. 10㎝ depth for 60minutes to heat 100 W of measurement agar... 163
Table 49. 10㎝ depth for 60minutes to heat 150 W of measurement agar... 165
Table 50. 15㎝ depth for 60minutes to heat 100 W of measurement agar... 167
Table 51. 15㎝ depth for 60minutes to heat 150 W of measurement agar... 169
Fig. 1. Numbers of cancer deaths during 2014 in Korea by sex 20
Fig. 2. Idealized radiation beam intensity profile of a typical accelerator... 35
Fig. 3. The cross beam profiles obtained for flatness also can be used for... 35
Fig. 4. Hyperthermia TCS System along with the computer. 38
Fig. 5. Display and the operating controls. 38
Fig. 6. Arm electrode and tile electrode. 41
Fig. 7. Choice of different electrode sizes. 42
Fig. 8. The structure of agar. 43
Fig. 9. Gel bolus. 44
Fig. 10. Multi-channel signal conditioner for applications using GaAs based... 45
Fig. 11. Fiber optic temperature sensor. 47
Fig. 12. The weight of the agar powder changes the permittivity 55
Fig. 13. Schematic image of agar phantom mold. 58
Fig. 14. Making of agar phantom mold. 59
Fig. 15. Agar powder of MSC Co. Ltd and sterile water. 60
Fig. 16. Yields of agar extracted 24hours after concentration. 60
Fig. 17. Making of agar phantom. 61
Fig. 18. Temperature measurement according to agar phantom ratio. 62
Fig. 19. Measuring of temperature on agar phantom. 63
Fig. 20. Illustration of simulation model on agar phantom. 64
Fig. 21. Illustration of simulation model on agar phantom of transverse... 65
Fig. 22. Illustration of simulation model on agar phantom in flatness. 65
Fig. 23. Illustration of simulation model on gel bolus phantom. 66
Fig. 24. Powder agar 4% mixing ratio. 68
Fig. 25. Powder agar 5% mixing ratio. 71
Fig. 26. Powder agar 6% mixing ratio. 74
Fig. 27. Broken agar phantom during temperature measurement. 77
Fig. 28. Powder agar 7% mixing ratio. 78
Fig. 29. Measurement of temperature after 3hours of agar phantom... 80
Fig. 30. Measurement of temperature after 22hours of agar phantom... 83
Fig. 31. Measurement of temperature after 49hours of agar phantom... 86
Fig. 32. Measurement of temperature after 72hours of agar phantom... 89
Fig. 33. Measurement of temperature after 96hours of agar phantom... 92
Fig. 34. Measurement of temperature after time of agar phantom production. 94
Fig. 35. The result of measuring the core body temperature from each... 95
Fig. 36. The result of measuring the core body temperature from each... 98
Fig. 37. The result of measuring the core body temperature from each... 101
Fig. 38. The result of measuring the core body temperature from each... 104
Fig. 39. The result of measuring the core body temperature from each... 107
Fig. 40. The result of measuring the core body temperature from each... 110
Fig. 41. The result of measuring the core body temperature from each... 113
Fig. 42. The result of measuring the core body temperature from each... 116
Fig. 43. The result of measuring the core body temperature from each... 119
Fig. 44. The result of measuring the core body temperature from each... 122
Fig. 45. The result of measuring the core body temperature from each... 125
Fig. 46. The result of measuring the core body temperature from each... 128
Fig. 47. The result of measuring the core body temperature from each... 131
Fig. 48. The result of measuring the core body temperature from each... 134
Fig. 49. The result of measuring the core body temperature from each... 137
Fig. 50. Temperature profile of transverse section along with 0㎝ depth. 140
Fig. 51. Temperature profile of transverse section along with 5㎝ depth. 143
Fig. 52. Temperature profile of transverse section along with 10㎝ depth. 146
Fig. 53. Temperature profile of transverse section along with 15㎝ depth. 149
Fig. 54. Depth of measurement temperature on gel bolus phantom for... 152
Fig. 55. Depth of measurement temperature on gel bolus phantom for... 155
Fig. 56. 5㎝ depth for 60minutes to heat 100 W of measurement agar... 158
Fig. 57. 5㎝ depth for 60minutes to heat 150 W of measurement agar... 160
Fig. 58. 10㎝ depth for 60minutes to heat 100 W of measurement agar... 162
Fig. 59. 10㎝ depth for 60minutes to heat 150 W of measurement agar... 164
Fig. 60. 15㎝ depth for 60minutes to heat 100 W of measurement agar... 166
Fig. 61. 15㎝ depth for 60minutes to heat 150 W of measurement agar... 168
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