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Title Page
Contents
요약 8
Introduction 10
Materials and Methods 13
1. Materials 13
2. Preparation of ozonated Antarctic krill oil (OAKO) 13
3. Microbial strains and cultures 13
4. Disk diffusion assay 14
5. Measurement of minimum inhibitory concentration (MIC) 14
6. Synergic effects between OAKO and antibiotics 16
7. Cell culture and viability assay 16
8. Nitric oxide (NO) assay 17
9. Western blot analysis 17
10. Reverse transcription-polymerase chain reaction (RT-PCR) analysis 18
11. Statistical analysis 18
Results and Discussion 20
1. Anti-bacterial effects of OAKO against skin pathogens 20
2. Determination of MIC of ozonated Antarctic krill oil 20
3. Antibiotic resistance of bacterial skin pathogens against antibiotics 22
4. Synergistic effects between OAKO and antibiotics 24
5. Cytotoxicity of the OAKO and inhibitory effect on NO production 29
6. Effects of the OAKO.144 on LPS-induced iNOS and COX-2 protein and mRNA expressions 32
7. Effects of the OAKO.144 on LPS-induced pro-inflammatory cytokines 32
8. Effect of OAKO.144 on LPS-induced MAPKs activation 35
Conclusions 38
References 40
Table 1. Disk diffusion assay of OAKO against bacterial skin pathogens 21
Table 2. MIC of OAKO against bacterial skin pathogens 23
Table 3. MIC of tetracycline, erythromycin and lincomycin against skin pathogens 25
Table 4. MIC and fractional inhibitory concentration (FIC) indices of OAKO in... 26
Table 5. MIC and FIC indices of OAKO in combination with antibiotics against... 27
Table 6. MIC and FIC indices of OAKO in combination with antibiotics against... 28
Fig. 1. Equipment of manufacturing for OAKO. 15
Fig. 2. Cytotoxicity effects of OAKO against RAW264.7 cells. The values are expressed... 30
Fig. 3. Effects of OAKO on the NO production of RAW264.7 cells. The values are... 31
Fig. 4. Inhibitory effects of the OAKO.144 in LPS-induced iNOS and COX-2 protein expression... 33
Fig. 5. Inhibitory effects of the OAKO.144 in LPS-induced iNOS and COX-2 mRNA expression... 34
Fig. 6. Inhibitory effects of the OAKO.144 on LPS-induced IL-1β, IL-6, and TNF-α production in RAW264.7 macrophages. The levels of IL-1β, IL-6, and TNF-α... 36
Fig. 7. Inhibitory effects of OAKO.144 on the protein level of p38, ERK and JNK in RAW264.7 macrophages. The levels of p-ERK, ERK, p-JNK, JNK, p-p38,... 37
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