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title page
Contents
List of Abbreviations 6
Abstract 11
1. Introduction 14
2. Materials and Methods 22
2-1. Test materials 22
2-2. Animals and husbandry 22
2-3. Fertility and developmental toxicity test 23
2-4. Peri/postnatal study 24
2-5. Behavioral testing in F1 offspring 25
2-6. Microarray analysis 26
2-7/2-5. Statistical analyses 28
3. Results 29
3-1. Fertility and developmental toxicity study 29
3-2. Peri/postnatal study 29
3-3. Behavioural testing in F1 offspring 30
3-4. Microarray analysis 31
4. Discussion 59
5. References 69
국문요약 94
Table 1. Absolute organ weights (g) of male mice treated for 28 days with Ecstasy. 36
Table 2. Absolute organ weights (g) of female mice treated for 28 days with Ecstasy. 37
Table 3. Hematology of male mice treated with Ecstasy for 28 days. 38
Table 4. Serum biochemistry of male mice treated with Ecstasy for 28 days. 40
Table 5. Copulation and fertility index in male and female mice (F0) treated with Ecstasy from 28 and 14 days, respectively, before mating.(이미지참조) 42
Table 6. Fetal implantation, mortality and external appearance from female mice examined on gestational day 18. 43
Table 7. Physical development and reflex of F₁ mice born of parents (F0) treated with Ecstasy.(이미지참조) 49
Table 8. Open field test of F₁ mice born of parents (F0) treated with Ecstasy.(이미지참조) 51
Figure 1. Chemical structures of hallucinogenic compound related with ecstasy. 21
Figure 2. Change in body weights of male mice treated with ecstasy for 28 days. 32
Figure 3. Change in body weights of female mice treated with ecstasy for 28 days. 33
Figure 4. Change in body weights of male mice treated with ecstasy from 28 days before mating to copulation. 34
Figure 5. Change in body weights of female mice treated with ecstasy from 14 days before mating to closure of the hard palate. 35
Figure 6. External malformations of fetus treated with ecstasy. 45
Figure 7. Skeletal or visceral appearance of fetus treated with ecstasy. 46
Figure 8. Change in body weights of F₁ male mice born of parents (F0) treated with ecstasy.(이미지참조) 47
Figure 9. Change in body weights of F₁ female mice born of parents (F0) treated with ecstasy.(이미지참조) 48
Figure 10. Hot plate test of F1 mice born of parents (F0) treated with ecstasy.(이미지참조) 52
Figure 11. Rotarod test of F1 mice born of parents (F0) treated with ecstasy.(이미지참조) 53
Figure 12. Fear conditioning test of F1 mice born of parents (F0) treated with ecsatsy.(이미지참조) 54
Figure 13. Passive avoidance test of F1 mice born of parents (F0) treated with ecstasy.(이미지참조) 55
Figure 14. Pattern of Gene clustering obtained from regions of control group brain. 56
Figure 15. Pattern of gene clustering obtained from regions of brain with ecstasy-treated. 57
Figure 16. Pattern of gene clustering obtained from cortex with ecstasy-treated. 58
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