생몰정보
소속
직위
직업
활동분야
주기
서지
국회도서관 서비스 이용에 대한 안내를 해드립니다.
검색결과 (전체 1건)
원문 있는 자료 (1) 열기
원문 아이콘이 없는 경우 국회도서관 방문 시 책자로 이용 가능
목차보기더보기
title page
Contents
(Abstract) 5
Introduction 7
Materials and methods 9
Materials 9
Degradation of HA 9
Preparation of cisplatin-incorporated nanoparticles of HA 10
Measurement of the drug contents and loading efficiency of nanoparticles of HA 10
Measurement by gel permeation chromatography(GPC) 11
Transmission electron microscopy (TEM) observation 11
Particle size and zeta potential measurement 11
X-ray powder diffractometry (XRD) measurement 12
Drug release study 12
Hyaluronidase extraction from tumor cell lines 12
Zymography of hyaluronic acid 13
Results 15
Characterization of degraded HA 15
Preparation of cisplatin-incorporated nanoparticles 15
Cisplatin release from nanoparticles 16
Discussion 18
Conclusion 20
References 21
〈초록〉 36
Table1. Characterization of cisplatin-incorporated HA nanoparticles 28
Fig. 1. Schematic illustrations of nanoparticle formation by ion complex between HA and cisplatin. Cisplatin incorporated HA nanoparticles are formed by ion complex between carboxyl groups... 29
Fig. 2. GPC chromatogram of degraded HA. the GPC system was composed of a waters 515 HPLC pump, waters 410 differential refractometer, waters 486 tunable absorbance detector,... 30
Fig. 3. Particle size distribution against drug contents. A sample solution prepared by the dialysis method was used for the particle size measurement (concentration: 0.1 w/v). 31
Fig. 4. Morphology of cisplatin-incorporated HA nanoparticles (100/10 of table 1 ) observed by TEM. A drop of nanoparticle suspension was placed onto a carbon film coated on a copper grid for TEM... 32
Fig. 5. XRD patterns of cisplatin-incorporated polymeric micelle of HAgPEG. cisplatin (a), HA (b), cisplatin-incorporated nanoparticles(100/5 in table 1) (c), cisplatin-incorporated nanoparticles (100/10) ... 33
Fig. 6. The effect of drug contents (a) and presence of hyaluronidase (b) on the cisplatin release from HA nanoparticles. the hyaluronidase (100 units/ml ) was added to the dialysis tube containing... 34
Fig.7. HA zymography using U343MG and U87MG cell lines (a). the effect of extracted hyaluronidase from U343MG and U87MG cell lines (b). the hyaluronidase activity was determined in the form... 35
원문구축 및 2018년 이후 자료는 524호에서 직접 열람하십시요.
도서위치안내: / 서가번호:
우편복사 목록담기를 완료하였습니다.
* 표시는 필수사항 입니다.
* 주의: 국회도서관 이용자 모두에게 공유서재로 서비스 됩니다.
저장 되었습니다.
로그인을 하시려면 아이디와 비밀번호를 입력해주세요. 모바일 간편 열람증으로 입실한 경우 회원가입을 해야합니다.
공용 PC이므로 한번 더 로그인 해 주시기 바랍니다.
아이디 또는 비밀번호를 확인해주세요
