This study identified effects of Isoegomaketone for applicable patch on the arthritis in mice.
Isoegomaketone (IK) was isolated from Perilla frutescens, which is annual herbal traditional medicinal,aromatic, functional food. IK has various physiological effects such as anti-inflammation, anti-oxidant,and anti-cancer. In the previous study, oral administration of IK to a mouse model of collagen antibodyinducedarthritis (CAIA), which is similar to human rheumatoid arthritis (RA), alleviated symptoms. In thisstudy, we attached a patch containing IK to mouse skin to demonstrate whether it had the same efficacyas oral administration in CAIA mouse. As a result of measuring the arthritis score, paw volume, andpaw thickness, it was confirmed that arthritis symptoms were alleviated in the group to which the patchcontaining IK was attached. These results show that IK is effective in alleviating arthritis not only throughoral administration but also through patches applied to skin, and that it has potential as a material forfuture patch development.