Title Page
Abstract
Contents
Ⅰ. Introduction 10
Ⅱ. Materials and Methods 14
2.1. Chemicals and reagents 14
2.2. Human liver microsome 15
2.3. Sample preparation 16
2.4. LC-Q-Tof-MS conditions 17
Ⅲ. Results and Discussion 19
Ⅳ. Conclusions 29
Reference 31
개요 33
Table 1. LC-Q-Tof-MS conditions 18
Table 2. Identified metabolites of carbodenafil 30
Figure 1. PDE 5 inhibitor mechanism of action 10
Figure 2. Structure of carbodenafils 12
Figure 3. Characteristic fragment ion of carbodenafil 19
Figure 4. Metabolites of carbodenafil pathways 20
Figure 5. Fragment ion of M1 21
Figure 6. Fragment ion of M2 22
Figure 7. Fragment ion of M3 23
Figure 8. Fragment ion of M4 24
Figure 9. Fragment ion of M5 25
Figure 10. Fragment ion of M6 26
Figure 11. Fragment ion of M7 27
Figure 12. Fragment ion of M8 28